Synthesis and anti-HCV activity of a new 2′-deoxy-2′-fluoro-2′-C-methyl nucleoside analogue

被引：20

作者：

Hu, Weidong ^{[1
]}

Wang, Ping'an ^{[2
]}

Song, Chuanjun ^{[1
]}

Pan, Zhenliang ^{[3
]}

Wang, Qiang ^{[1
]}

Guo, Xiaohe ^{[4
]}

Yu, Xuejun

Shen, Zhenhua ^{[1
]}

Wang, Shuyang ^{[1
]}

Chang, Junbiao ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Zhengzhou 450001, Henan Province, Peoples R China

[2] Henan Univ, Coll Chem & Chem Engn, Kaifen 475001, Henan Province, Peoples R China

[3] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan Province, Peoples R China

[4] Henan Acad Sci, Hennan Key Lab Fine Chem, Zhengzhou 450002, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 24期

基金：

中国国家自然科学基金;

关键词：

2 '-Deoxy-2 '-fluoro-2 '-C-methyl nucleoside; Anti-HCV activity; C VIRUS-REPLICATION; HEPATITIS-C; RNA REPLICATION; INHIBITION; DESIGN; HIV;

D O I：

10.1016/j.bmcl.2010.10.076

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

2'-Deoxy-2'-fluoro-2'-C-methyl nucleoside analogue 4 was designed and synthesized. Initial biological studies indicated that this compound showed promising activity against HCV replication. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7297 / 7298

页数：2

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