CATCHR, HOPS and CORVET tethering complexes share a similar architecture

被引：65

作者：

Chou, Hui-Ting ^{[1
]}

Dukovski, Danijela ^{[1
,3
]}

Chambers, Melissa G. ^{[1
]}

Reinisch, Karin M. ^{[2
]}

Walz, Thomas ^{[1
,4
]}

机构：

[1] Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA

[2] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA

[3] Proteostasis Therapeut, Cambridge, MA USA

[4] Rockefeller Univ, Lab Mol Electron Microscopy, 1230 York Ave, New York, NY 10021 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 08期

关键词：

STRUCTURAL BASIS; GARP COMPLEX; COG COMPLEX; PROTEIN; SUBUNIT;

D O I：

10.1038/nsmb.3264

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We show here that the Saccharomyces cerevisiae GARP complex and the Cog1-4 subcomplex of the COG complex, both members of the complexes associated with tethering containing helical rods (CATCHR) family of multisubunit tethering complexes, share the same subunit organization. We also show that HOPS, a tethering complex acting in the endolysosomal pathway, shares a similar architecture, thus suggesting that multisubunit tethering complexes use related structural frameworks.

引用

页码：761 / +

页数：4

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