The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA

被引：64

作者：

Croft, M ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, Div Mol Immunol, San Diego, CA 92121 USA

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 06期

关键词：

D O I：

10.1016/j.it.2005.03.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Receptors and their ligands on T cells and antigen-presenting cells are crucial for delivering inhibitory or stimulatory signals that enable immune cells to remain dormant or to respond effectively to various stimuli. The CD28-B7 and tumor necrosis factor receptor (TNFR)-TNF superfamilies contain many of these molecules and were thought to be distinct functioning modules. However, two studies have now provided a new perspective in this already complex area, showing not only a crosstalk between these superfamilies but potentially between co-stimulatory and co-inhibitory receptors.

引用

页码：292 / 294

页数：3

共 22 条

[1] Herpes simplex virus glycoprotein D bound to the human receptor HveA [J].

Carfí, A ;

Willis, SH ;

Whitbeck, JC ;

Krummenacher, C ;

Cohen, GH ;

Eisenberg, RJ ;

Wiley, DC .

MOLECULAR CELL, 2001, 8 (01) :169-179

[2] Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity [J].

Chen, LP .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (05) :336-347

[3] Co-stimulatory members of the TNFR family: Keys to effective T-cell immunity? [J].

Croft, M .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (08) :609-620

[4] Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2 [J].

Gavrieli, M ;

Watanabe, N ;

Loftin, SK ;

Murphy, TL ;

Murphy, KM .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 312 (04) :1236-1243

[5] A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator [J].

Gonzalez, LC ;

Loyet, KM ;

Calemine-Fenaux, J ;

Chauhan, V ;

Wranik, B ;

Ouyang, W ;

Eaton, DL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (04) :1116-1121

[6] An inhibitory Ig superfamily protein expressed by lymphocytes and APCs is also an early marker of thymocyte positive selection [J].

Han, P ;

Goularte, OD ;

Rufner, K ;

Wilkinson, B ;

Kaye, J .

JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :5931-5939

[7] Herpesvirus entry mediator ligand (HVEM-L), a novel ligand for HVEM/TR2, stimulates proliferation of T cells and inhibits HT29 cell growth [J].

Harrop, JA ;

McDonnell, PC ;

Brigham-Burke, M ;

Lyn, SD ;

Minton, J ;

Tan, KB ;

Dede, K ;

Spampanato, J ;

Silverman, C ;

Hensley, P ;

DiPrinzio, R ;

Emery, JG ;

Deen, K ;

Eichman, C ;

Chabot-Fletcher, M ;

Truneh, A ;

Young, PR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (42) :27548-27556

[8] Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappa B and AP-1 [J].

Marsters, SA ;

Ayres, TM ;

Skubatch, M ;

Gray, CL ;

Rothe, M ;

Ashkenazi, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (22) :14029-14032

[9] LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator [J].

Mauri, DN ;

Ebner, R ;

Montgomery, RI ;

Kochel, KD ;

Cheung, TC ;

Yu, GL ;

Ruben, S ;

Murphy, M ;

Eisenberg, RJ ;

Cohen, GH ;

Spear, PG ;

Ware, CF .

IMMUNITY, 1998, 8 (01) :21-30

[10] Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family [J].

Montgomery, RI ;

Warner, MS ;

Lum, BJ ;

Spear, PG .

CELL, 1996, 87 (03) :427-436

← 1 2 3 →