Q Fever in France, 1985-2009

被引:100
作者
Frankel, Diane [1 ]
Richet, Herve [1 ]
Renvoise, Aurelie [1 ]
Raoult, Didier [1 ]
机构
[1] Univ Mediterranee, Inst Rech & Dev 3R198, Fac Med, Unite Mixte Rech 6236, F-13385 Marseille 05, France
关键词
EPIDEMIOLOGY; DIAGNOSIS;
D O I
10.3201/eid1703.100882
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
To assess Q fever in France, we analyzed data for 1985-2009 from the French National Reference Center. A total of 179,794 serum samples were analyzed; 3,723 patients (one third female patients) had acute Q fever. Yearly distribution of acute Q fever showed a continuous increase. Periodic variations were observed in monthly distribution during January 2000 December 2009; cases peaked during April-September. Q fever was diagnosed more often in patients in southeastern France, where our laboratory is situated, than in other areas. Reevaluation of the current positive predictive value of serologic analysis for endocarditis was performed. We propose a change in the phase I (virulent bacteria) immunoglobulin G cutoff titer to >= 1,600. Annual incidences of acute Q fever and endocarditis were 2.5/100,000 persons and 0.1/100,000 persons, respectively. Cases and outbreaks of Q fever have increased in France.
引用
收藏
页码:350 / 356
页数:7
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