Recent advances in sialidase inhibitors

被引：7

作者：

Dowle, MD ^{[1
]}

Howes, PD ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 1998年 / 8卷 / 11期

关键词：

antibacterial; antiviral; influenza; neuraminidase; sialidase; viruses;

D O I：

10.1517/13543776.8.11.1461

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Viruses and bacteria cause diseases of vast economic importance. Sialidase inhibitors offer an opportunity to prevent or ameliorate these diseases. They have been investigated ostensibly as antiviral agents particularly against influenza viruses. The patent literature covering sialidase inhibitor compounds, their design and synthesis is reviewed from 1995 to mid-1998 with reference to the primary scientific literature. Patents are discussed by company or institution. The importance of different compound types is indicated.

引用

页码：1461 / 1478

页数：18

共 31 条

[1]

ATIGADDA V, 1997, 213 ACS NAT M SAN FR

[2] Neuraminidase inhibitors as potential anti-influenza drugs [J].

Bamford, MJ .

JOURNAL OF ENZYME INHIBITION, 1995, 10 (01) :1-16

[3] PKAS OF IONIZABLE GROUPS IN PROTEINS - ATOMIC DETAIL FROM A CONTINUUM ELECTROSTATIC MODEL [J].

BASHFORD, D ;

KARPLUS, M .

BIOCHEMISTRY, 1990, 29 (44) :10219-10225

[4] Synthesis of phosphonic acid analogues of sialic acids (Neu5Ac and KDN) as potential sialidase inhibitors [J].

Chan, TH ;

Xin, YC ;

vonItzstein, M .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (11) :3500-3504

[5] Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design [J].

Chand, P ;

Babu, YS ;

Bantia, S ;

Chu, NM ;

Cole, LB ;

Kotian, PL ;

Laver, WG ;

Montgomery, JA ;

Pathak, VP ;

Petty, SL ;

Shrout, DP ;

Walsh, DA ;

Walsh, GW .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (25) :4030-4052

[6] ELECTROSTATICS AND DIFFUSION OF MOLECULES IN SOLUTION - SIMULATIONS WITH THE UNIVERSITY-OF-HOUSTON-BROWNIAN DYNAMICS PROGRAM [J].

DAVIS, ME ;

MADURA, JD ;

LUTY, BA ;

MCCAMMON, JA .

COMPUTER PHYSICS COMMUNICATIONS, 1991, 62 (2-3) :187-197

[7]

DUARTE FJ, 1997, 213 ACS NAT M SAN FR

[8] CALCULATING THE ELECTROSTATIC POTENTIAL OF MOLECULES IN SOLUTION - METHOD AND ERROR ASSESSMENT [J].

GILSON, MK ;

SHARP, KA ;

HONIG, BH .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1988, 9 (04) :327-335

[9] NEURAMINIDASE - THE SPECIFIC ENZYME OF INFLUENZA VIRUS AND VIBRIO-CHOLERAE [J].

GOTTSCHALK, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1957, 23 (03) :645-646

[10] Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections [J].

Hayden, FG ;

Osterhaus, ADME ;

Treanor, JJ ;

Fleming, DM ;

Aoki, FY ;

Nicholson, KG ;

Bohnen, AM ;

Hirst, HM ;

Keene, O ;

Wightman, K .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (13) :874-880

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