Long-term epidemiological survey of Candida species:: comparison of isolates found in an intensive care unit and in conventional wards

被引:17
作者
Leone, M [1 ]
Albanèse, J
Antonini, F
Michel-Nguyen, A
Blanc-Bimar, MC
Martin, C
机构
[1] Marseilles Univ Hosp Syst, Nord Hosp, Marseilles Sch Med, Intens Care Unit, Marseille, France
[2] Marseilles Univ Hosp Syst, Nord Hosp, Marseilles Sch Med, Bacteriol Lab, Marseille, France
关键词
candido; hospital-acquired infection; intensive care unit; fluconazole;
D O I
10.1016/j.jhin.2003.07.003
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
The aim of this study was to compare the distribution of Candida species in patients hospitalized in an intensive care unit (ICU) and in conventional wards. A retrospective analysis was performed covering an 18-year period in a 700-bed teaching hospital. Various body sites were investigated in all patients admitted during the study and isolates were identified by microscopic and macroscopic morphology, and by commercially available kits. The susceptibility of strains to amphotericin B and flucytosine was assessed by the ATB-fungus(R) system, itraconazole and fluconazole by Etest(R). No difference was observed between the distribution of Candida species in ICU and in conventional wards. Candida albicans represented about 70% of isolates and Candida glabrata was the second most common species involved in infection or colonization. The small number of C. glabrata resistant to fluconazole suggested this antifungal agent as suitable empirical treatment for non-immunocompromized patients in whom a fungal infection was suspected. (C) 2003 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:169 / 174
页数:6
相关论文
共 24 条
[1]   The epidemiology of hematogenous candidiasis caused by different Candida species [J].
AbiSaid, D ;
Anaissie, E ;
Uzun, O ;
Raad, I ;
Pinzcowski, H ;
Vartivarian, S .
CLINICAL INFECTIOUS DISEASES, 1997, 24 (06) :1122-1128
[2]  
BECKSAGUE CM, 1993, J INFECT DIS, V167, P1247, DOI 10.1093/infdis/167.5.1247
[3]   Trends in antifungal use and epidemiology of nosocomial yeast infections in a university hospital [J].
Berrouane, YF ;
Herwaldt, LA ;
Pfaller, MA .
JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (03) :531-537
[4]   Trends in frequency and susceptibilities of Candida glabrata bloodstream isolates at a University Hospital [J].
Braddley, JW ;
Smith, AM ;
Moser, SA ;
Pappas, PG .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2001, 39 (03) :199-201
[5]   EVALUATION OF THE E-TEST SYSTEM VERSUS A MICROTITRE BROTH METHOD FOR ANTIFUNGAL SUSCEPTIBILITY TESTING OF YEASTS AGAINST FLUCONAZOLE AND ITRACONAZOLE [J].
COLOMBO, AL ;
BARCHIESI, F ;
MCGOUGH, DA ;
FOTHERGILL, AW ;
RINALDI, MG .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1995, 36 (01) :93-100
[6]  
FRICKERHIDALGO H, 1995, ANN BIOL CLIN-PARIS, V53, P221
[7]   Surveillance of antimicrobial use and antimicrobial resistance in United States hospitals: Project ICARE phase 2 [J].
Fridkin, SK ;
Steward, CD ;
Edwards, JR ;
Pryor, ER ;
McGowan, JE ;
Archibald, LK ;
Gaynes, RP ;
Tenover, FC .
CLINICAL INFECTIOUS DISEASES, 1999, 29 (02) :245-252
[8]   Increasing prevalence of antimicrobial resistance in intensive care units [J].
Fridkin, SK .
CRITICAL CARE MEDICINE, 2001, 29 (04) :N64-N68
[9]   Subtyping and antifungal susceptibilities of Candida spp. in the intensive care unit of a Greek general hospital [J].
Kanellopoulou, M ;
Stamos, G ;
Petinnelli, I ;
Savala, M ;
Tzimogianni, A ;
Legakis, NJ ;
Foustoukou, M ;
Papafragas, E ;
Velegraki, A .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 18 (02) :179-183
[10]   Antibiotic resistance in the intensive care unit [J].
Kollef, MH ;
Fraser, VJ .
ANNALS OF INTERNAL MEDICINE, 2001, 134 (04) :298-314