Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs

被引：342

作者：

Martel-Pelletier, J ^{[1
]}

Lajeunesse, D ^{[1
]}

Reboul, P ^{[1
]}

Pelletier, JP ^{[1
]}

机构：

[1] Univ Montreal, Osteoarthritis Res Unit, Ctr Hosp, Notre Dame Hosp, Montreal, PQ H2L 4M1, Canada

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2003年 / 62卷 / 06期

关键词：

D O I：

10.1136/ard.62.6.501

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dual 5-LOX/COX inhibitors are potential new drugs to treat inflammation. They act by blocking the formation of both prostaglandins and leucotrienes but do not affect lipoxin formation. Such combined inhibition avoids some of the disadvantages of selective COX-2 inhibitors and spares the gatrointestinal mucosa.

引用

页码：501 / 509

页数：9

共 104 条

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