Novel cytotoxic diterpenes, excavatolides A-E, isolated from the Formosan gorgonian Briareum excavatum

被引：74

作者：

Sheu, JH ^{[1
]}

Sung, PJ

Cheng, MC

Liu, HY

Fang, LS

Duh, CY

Chiang, MY

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 05期

关键词：

D O I：

10.1021/np970553w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The chemistry of Briareum excavatum, a Formosan gorgonian coral, was investigated. This study has led to the isolation of five novel marine natural products, excavatolides A-E (1-5), together with brianolide (6). The structures of the above compounds were established by spectral and chemical methods. The relative configuration of excavatolide B (2) was further confirmed by a single-crystal X-ray structure analysis. Cytotoxicity of these compounds toward various cancer cell lines also is described.

引用

页码：602 / 608

页数：7

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