The challenge of treating biofilm-associated bacterial infection

被引：458

作者：

del Pozo, J. L.

Patel, R. ^{[1
]}

机构：

[1] Mayo Clin, Div Infect Dis, Rochester, MN 55905 USA

[2] Mayo Clin, Div Clin Microbiol, Rochester, MN USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 82卷 / 02期

关键词：

D O I：

10.1038/sj.clpt.6100247

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents. Bacterial biofilms have several potential antimicrobial resistance mechanisms. Antimicrobial resistance mechanisms may act concurrently, and in some cases, synergistically. Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents. Understanding the mechanisms involved in biofilm-associated antimicrobial resistance is key to development of new therapeutic strategies.

引用

收藏

页码：204 / 209

页数：6

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