The challenge of treating biofilm-associated bacterial infection

被引：462

作者：

del Pozo, J. L.

Patel, R. ^{[1
]}

机构：

[1] Mayo Clin, Div Infect Dis, Rochester, MN 55905 USA

[2] Mayo Clin, Div Clin Microbiol, Rochester, MN USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 82卷 / 02期

关键词：

D O I：

10.1038/sj.clpt.6100247

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Biofilm formation is a crucial step in the pathogenesis of many subacute and chronic bacterial infections, including foreign body-related infections. Biofilms are difficult to eradicate with conventional antimicrobial agents. Bacterial biofilms have several potential antimicrobial resistance mechanisms. Antimicrobial resistance mechanisms may act concurrently, and in some cases, synergistically. Persister cells play a major role in the tolerance of biofilm bacteria to antimicrobial agents. Understanding the mechanisms involved in biofilm-associated antimicrobial resistance is key to development of new therapeutic strategies.

引用

收藏

页码：204 / 209

页数：6

相关论文

共 30 条

[1] Extracellular products as mediators of the formation and detachment of Pseudomonas fluorescens biofilms [J].

Allison, DG ;

Ruiz, B ;

SanJose, C ;

Jaspe, A ;

Gilbert, P .

FEMS MICROBIOLOGY LETTERS, 1998, 167 (02) :179-184

[2] Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin [J].

Anderl, JN ;

Franklin, MJ ;

Stewart, PS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (07) :1818-1824

[3] Intracellular bacterial biofilm-like pods in urinary tract infections [J].

Anderson, GG ;

Palermo, JJ ;

Schilling, JD ;

Roth, R ;

Heuser, J ;

Hultgren, SJ .

SCIENCE, 2003, 301 (5629) :105-107

[4] Dynamics and spatial distribution of β-lactamase expression in Pseudomonas aeruginosa biofilms [J].

Bagge, N ;

Hentzer, M ;

Andersen, JB ;

Ciofu, O ;

Givskov, M ;

Hoiby, N .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (04) :1168-1174

[5] A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms [J].

Brooun, A ;

Liu, SH ;

Lewis, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (03) :640-646

[6] A radio frequency electric current enhances antibiotic efficacy against bacterial biofilms [J].

Caubet, R ;

Pedarros-Caubet, F ;

Chu, M ;

Freye, E ;

Rodrigues, MD ;

Moreau, JM ;

Ellison, WJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (12) :4662-4664

[7] RNAIII-inhibiting peptide significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of central venous catheter -: Associated Staphylococcus aureus infections [J].

Cirioni, O ;

Giacometti, A ;

Ghiselli, R ;

Dell'Acqua, G ;

Orlando, F ;

Mocchegiani, F ;

Silvestri, C ;

Licci, A ;

Saba, V ;

Scalise, G ;

Balaban, N .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (02) :180-186

[8] BIOFILMS, THE CUSTOMIZED MICRONICHE [J].

COSTERTON, JW ;

LEWANDOWSKI, Z ;

DEBEER, D ;

CALDWELL, D ;

KORBER, D ;

JAMES, G .

JOURNAL OF BACTERIOLOGY, 1994, 176 (08) :2137-2142

[9] Current concepts - Treatment of infections associated with surgical implants [J].

Darouiche, RO .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (14) :1422-1429

[10] VANCOMYCIN PENETRATION INTO BIOFILM COVERING INFECTED PROSTHESES AND EFFECT ON BACTERIA [J].

DAROUICHE, RO ;

DHIR, A ;

MILLER, AJ ;

LANDON, GC ;

RAAD, II ;

MUSHER, DM .

JOURNAL OF INFECTIOUS DISEASES, 1994, 170 (03) :720-723