NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

被引：787

作者：

Caruso, Roberta ^{[1
,2
]}

Warner, Neil ^{[1
,2
]}

Inohara, Naohiro ^{[1
,2
]}

Nunez, Gabriel ^{[1
,2
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

IMMUNITY | 2014年 / 41卷 / 06期

关键词：

NF-KAPPA-B; INTESTINAL EPITHELIAL-CELLS; OLIGOMERIZATION DOMAIN 1; HUMAN DENDRITIC CELLS; IMMUNE RECEPTOR NOD1; ILEAL CROHNS-DISEASE; BACTERIAL PEPTIDOGLYCAN; MURAMYL DIPEPTIDE; NEUTROPHIL RECRUITMENT; DIAMINOPIMELIC ACID;

D O I：

10.1016/j.immuni.2014.12.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2, the founding members of the intracellular NOD-like receptor family, sense conserved motifs in bacterial peptidoglycan and induce proinflammatory and antimicrobial responses. Here, we discuss recent developments about the mechanisms by which NOD1 and NOD2 are activated by bacterial ligands, the regulation of their signaling pathways, and their role in host defense and inflammatory disease. Several routes for the entry of peptidoglycan ligands to the host cytosol to trigger activation of NOD1 and NOD2 have been elucidated. Furthermore, genetic screens and biochemical analyses have revealed mechanisms that regulate NOD1 and NOD2 signaling. Finally, recent studies have suggested several mechanisms to account for the link between NOD2 variants and susceptibility to Crohn's disease. Further understanding of NOD1 and NOD2 should provide new insight into the pathogenesis of disease and the development of new strategies to treat inflammatory and infectious disorders.

引用

页码：898 / 908

页数：11

共 131 条

[1]

Structure-Activity Relationships in Nucleotide Oligomerization Domain 1 (Nod1) Agonistic γ-Glutamyldiaminopimelic Acid Derivatives [J].

Agnihotri, Geetanjali ;

Ukani, Rehman ;

Malladi, Subbalakshmi S. ;

Warshakoon, Hemamali J. ;

Balakrishna, Rajalakshmi ;

Wang, Xinkun ;

David, Sunil A. .

JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (05) :1490-1510

[2]

Helicobacter pylori Induces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism [J].

Allison, Cody C. ;

Kufer, Thomas A. ;

Kremmer, Elisabeth ;

Kaparakis, Maria ;

Ferrero, Richard L. .

JOURNAL OF IMMUNOLOGY, 2009, 183 (12) :8099-8109

[3]

GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells [J].

Barnich, N ;

Hisamatsu, T ;

Aguirre, JE ;

Xavier, R ;

Reinecker, HC ;

Podolsky, DK .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (19) :19021-19026

[4]

Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-κB [J].

Bertin, J ;

Nir, WJ ;

Fischer, CM ;

Tayber, OV ;

Errada, PR ;

Grant, JR ;

Keilty, JJ ;

Gosselin, ML ;

Robison, KE ;

Wong, GHW ;

Glucksmann, MA ;

DiStefano, PS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) :12955-12958

[5]

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2 [J].

Bertrand, Mathieu J. M. ;

Doiron, Karine ;

Labbe, Katherine ;

Korneluk, Robert G. ;

Barker, Philip A. ;

Saleh, Maya .

IMMUNITY, 2009, 30 (06) :789-801

[6]

Anti-inflammatory Arene-Chromium Complexes Acting as Specific Inhibitors of NOD2 Signalling [J].

Bielig, Harald ;

Velder, Janna ;

Saiai, Aroonchai ;

Menning, Maureen ;

Meemboor, Sonja ;

Kalka-Moll, Wiltrud ;

Kroenke, Martin ;

Schmalz, Hans-Guenther ;

Kufer, Thomas A. .

CHEMMEDCHEM, 2010, 5 (12) :2065-2071

[7]

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system [J].

Boneca, Ivo G. ;

Dussurget, Olivier ;

Cabanes, Didier ;

Nahori, Marie-Anne ;

Sousa, Sandra ;

Lecuit, Marc ;

Psylinakis, Emmanuel ;

Bouriotis, Vassilis ;

Hugot, Jean-Pierre ;

Giovannini, Marco ;

Coyle, Anthony ;

Bertin, John ;

Namane, Abdelkader ;

Rousselle, Jean-Claude ;

Cayet, Nadege ;

Prevost, Marie-Christine ;

Balloy, Viviane ;

Chignard, Michel ;

Philpottt, Dana J. ;

Cossart, Pascale ;

Girardin, Stephen E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :997-1002

[8]

The Intracellular Sensor NOD2 Induces MicroRNA-29 Expression in Human Dendritic Cells to Limit IL-23 Release [J].

Brain, Oliver ;

Owens, Benjamin M. J. ;

Pichulik, Tica ;

Allan, Philip ;

Khatamzas, Elham ;

Leslie, Alasdair ;

Steevels, Tessa ;

Sharma, Sameer ;

Mayer, Alice ;

Catuneanu, Ana Maria ;

Morton, Victoria ;

Sun, Mei-Yi ;

Jewell, Derek ;

Coccia, Margherita ;

Harrison, Oliver ;

Maloy, Kevin ;

Schoenefeldt, Susann ;

Bornschein, Simon ;

Liston, Adrian ;

Simmons, Alison .

IMMUNITY, 2013, 39 (03) :521-536

[9]

Infection Mobilizes Hematopoietic Stem Cells through Cooperative NOD-like Receptor and Toll-like Receptor Signaling [J].

Burberry, Aaron ;

Zeng, Melody Y. ;

Ding, Lei ;

Wicks, Ian ;

Inohara, Naohiro ;

Morrison, Sean J. ;

Nunez, Gabriel .

CELL HOST & MICROBE, 2014, 15 (06) :779-791

[10]

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells [J].

Cadwell, Ken ;

Liu, John Y. ;

Brown, Sarah L. ;

Miyoshi, Hiroyuki ;

Loh, Joy ;

Lennerz, Jochen K. ;

Kishi, Chieko ;

Kc, Wumesh ;

Carrero, Javier A. ;

Hunt, Steven ;

Stone, Christian D. ;

Brunt, Elizabeth M. ;

Xavier, Ramnik J. ;

Sleckman, Barry P. ;

Li, Ellen ;

Mizushima, Noboru ;

Stappenbeck, Thaddeus S. ;

Virgin, Herbert W. .

NATURE, 2008, 456 (7219) :259-U62

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