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Branched-chain amino acids improve insulin resistance in patients with hepatitis C virus-related liver disease: report of two cases

被引：36
作者：
Kawaguchi, Takumi
Taniguchi, Eitaro
Itou, Minoru
Sumie, Shuji
Oriishi, Tetsuharu
Matsuoka, Hisako
Nagao, Yumiko
Sata, Michio
机构：
[1] Kurume Univ, Sch Med, Dept Digest Dis Informat & Res, Kurume, Fukuoka 8300011, Japan
[2] Kurume Univ, Sch Med, Dept Med, Div Gastroenterol, Kurume, Fukuoka 830, Japan
来源：
LIVER INTERNATIONAL | 2007年 / 27卷 / 09期
关键词：
branched-chain amino acids; hepatitis C virus; insulin resistance; lipid metabolism; nutritional support; protein-energy malnutrition;
D O I：
10.1111/j.1478-3231.2007.01559.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatitis C virus (HCV) infection causes insulin resistance. Because increased insulin resistance is a risk factor for development of hepatocellular carcinoma and reduced long-term survival, insulin resistance is a therapeutic target in patients with HCV infection. Branched-chain amino acids (BCAAs) are not only structural constituents of proteins but they are also considered as regulators of insulin signalling. We first describe two cases suggesting that administration of BCAAs improves insulin resistance associated with HCV-related liver disease. Although there were no changes in body weight, plasma glucose concentration and haemoglobin A1c (HbA1c) value were decreased. Moreover, BCAAs caused a decrease in both fasting insulin concentration and the value of homeostasis model assessment for insulin resistance. Thus, BCAAs are a potential therapeutic agent for improving insulin resistance in patients with HCV-related liver disease.
引用
收藏
页码：1287 / 1292
页数：6
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