Adjuvant effects of fluoride on oral immunization of chickens

被引：24

作者：

Hoshi, S ^{[1
]}

Saito, N ^{[1
]}

Kusanagi, K ^{[1
]}

Ihara, T ^{[1
]}

Ueda, S ^{[1
]}

机构：

[1] Nippon Inst Biol Sci, Tokyo 198, Japan

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1998年 / 63卷 / 03期

关键词：

oral immunization; NaF; chicken;

D O I：

10.1016/S0165-2427(98)00103-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study was conducted to examine the antibody responses of chickens after oral immunization and the influence of sodium fluoride (NaF) on their immunological states. Bovine serum albumin (BSA) was used as an antigen, and the response was measured by enzyme-linked immunosorbent assays of serum samples, bile samples, and lachrymal fluids. Oral immunization of chickens with antigen alone hardly induced antibody responses in sera, bile samples or lachrymal fluids. Moreover, compared to control chickens, these orally immunized chickens exhibited a lower serum IgG response to subsequent parenteral immunization, suggesting that oral immunization induced immunological tolerance in chickens. A mucosal adjuvant, NaF, could abrogate oral tolerance and elicit an increase in antibody responses. Chickens, which received oral administration of antigen and NaF simultaneously, showed a significant rise in serum IgG antibody. Although there were variations among individual chickens and the titers were low, IgA antibodies were detected in bile samples and lachrymal fluids. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：253 / 263

页数：11

共 24 条

[1] STIMULATION OF LACHRYMATION AND SALIVATION IN ADULT FOWL (GALLUS-DOMESTICUS) [J].