Reduced CD127 expression on peripheral CD4+ T cells impairs immunological recovery in course of suppressive highly active antiretroviral therapy

被引:25
作者
Bai, Francesca [1 ]
Bellistri, Giusi M.
Tincati, Camilla
Savoldi, Alessia
Pandolfo, Alessandro
Bini, Teresa
Carpani, Giovanni [2 ]
Sinigaglia, Elisabetta [2 ]
Marchetti, Giulia
Monforte, Antonella d'Arminio
机构
[1] Univ Milan, San Paolo Hosp, Clin Infect Dis & Trop Med, Dept Med Surg & Dent, I-20142 Milan, Italy
[2] San Paolo Hosp, Ctr Blood Transfus, Milan, Italy
关键词
VIRAL SUPPRESSION; LATE PRESENTERS; ACTIVATION; RESPONSES; INTERLEUKIN-7; INFECTION; HAART; CD38; ERA;
D O I
10.1097/QAD.0b013e32833f9d64
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Inefficient immune recovery under highly active antiretroviral therapy (HAART) represents a clinical issue. Twenty-seven of 121 HIV + naive patients became immunological nonresponders (INRs) and 55 introduced therapy late [very late treated (VLT)]. INR displayed older age, lower CD4(+) cell counts, down-regulation of CD127(+)CD4(+) and higher apoptotic CD95(+)CD8(+). VLT also showed higher activated CD38(+)CD8(+)%. The only factor associated with INR status was CD127(+)CD4(+)%. INR showed lower baseline interleukin (IL)-7 levels and a reduced expression of IL-7R (CD127) on naive and memory T-cells, reaching significance in memory CD127(+)CD45R0(+)CD4(+). These results suggest a possible role for the IL-7/IL-7R system in the pathogenesis of poor immunological recovery during HAART.
引用
收藏
页码:2581 / 2584
页数:4
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