Diet, smoking and lung cancer: a case-control study of 1000 cases and 1500 controls in South-West England

被引:38
作者
Darby, S
Whitley, E
Doll, R
Key, T
Silcocks, P
机构
[1] Radcliffe Infirm, Imperial Canc Res Fund, MRC, BHF Clin Trial Serv Unit, Oxford OX2 6HE, England
[2] Radcliffe Infirm, Epidemiol Studies Unit, Oxford OX2 6HE, England
[3] Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England
[4] Radcliffe Infirm, Imperial Canc Res Fund, Canc Epidemiol Unit, Oxford OX2 6HE, England
[5] Queens Med Ctr, Trent Inst Hlth Serv Res, Nottingham NG7 2UH, England
关键词
diet; lung cancer; carotene; retinol;
D O I
10.1054/bjoc.2000.1668
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We have examined the relationship between diet and lung cancer in a case-control study of 982 cases of lung cancer and 1486 population controls in south-west England in which subjects were interviewed personally about their smoking habits and their consumption of foods and supplements rich in retinol or carotene. Analyses were performed for 15 dietary variables, including intake of preformed retinol and carotene. There were significant associations (P < 0.01) with lung cancer risk for 13 of the variables, eight of which remained after adjustment for smoking. When the 15 variables were considered simultaneously, independent significant associations remained for 5: pre-formed retinol (increased risk), and fish liver oil, vitamin pills, carrots and tomato sauce (decreased risk), It is unlikely that all five associations represent biological effects, or that they can all be explained by residual confounding by smoking, or by biases. We conclude that there is at least one as yet unidentified factor that is causally related to lung cancer risk and of considerable importance in terms of attributable risk in this population. (C) 2001 Cancer Research Campaign.
引用
收藏
页码:728 / 735
页数:8
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