Stimulatory effects of starfish sapogenins (Asterias amurensis and Lethasterias nanimensis chelifera) on molluscan heart (Spisula sachalinensis)

被引：10

作者：

Gorshkov, BA ^{[1
]}

Kapustina, II ^{[1
]}

Kicha, AA ^{[1
]}

Aminin, DL ^{[1
]}

Gorshkova, IA ^{[1
]}

机构：

[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Lab Chem Marine Nat Prod, Far E Div, Vladivostok 690022, Russia

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1998年 / 120卷 / 02期

关键词：

asterosaponins; Ca2+ influx; contractile force; molluscan heart; ouabain; rat brain Na+; K+-ATPase; starfish sapogenins; Asterias amurensis; Lethasterias nanimensis chelifera; Spisula sachalinensis;

D O I：

10.1016/S0742-8413(98)10001-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Sapogenins from the starfish Asterias amurensis and Lethasterias nanimensis chelifera, 5 alpha-pregn-9(11)-ene-3 beta,6 alpha -diol-20-one, 5 alpha-cholest-9(11)-ene-3 beta,6 alpha-diol-23-one, 5 alpha-cholesta-9(11),24(25)-diene-3 beta,6 alpha-diol-23-one, (20E)-5 alpha-cholesta-9(11),20(22)-diene-3 beta,6 alpha- diol-23-one and 24 xi-methyl-5 alpha-cholesta-9(11),20(22)-diene-3 beta,6 alpha-diol-23-one, stimulated the contractile force of the heart of the mollusk Spisula sachalinensis at concentration of 5 x 10(-5) M. Ouabain, a specific inhibitor of Na+,K+-ATPase, at concentration of 5 x 10(-5) M had no effect on this physiological model. Starfish sapogenins of the cholestane series moderately inhibited rat brain cortex Na+,K+-ATPase and decreased Ca2+ influx into Ehrlich carcinoma cells. In contrast, pregnane asterogenin asterone did not inhibit Na+,K+-ATPase and increased the influx of Ca2+ into cells. These effects were not the result of cell membrane damage, because none of the compounds tested have hemolytic activity. (C) 1998 Elsevier Science Inc. AU rights reserved.

引用

页码：235 / 239

页数：5

共 28 条

[1]

BIOLOGICAL-ACTIVITY OF SAPONINS AND SAPONIN-LIKE COMPOUNDS FROM STARFISH AND BRITTLE-STARS [J].