Effects of inhaled oxygen concentration on fat metabolism during propofol infusion in rabbits

被引：4

作者：

Tsubokawa, T ^{[1
]}

Yamamoto, K ^{[1
]}

Nishimura, K ^{[1
]}

Yagi, T ^{[1
]}

Kobayashi, T ^{[1
]}

机构：

[1] Kanazawa Univ, Fac Med, Sch Med, Dept Anaesthesiol & Intens Care Med, Kanazawa, Ishikawa 9208641, Japan

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1998年 / 81卷 / 05期

关键词：

anaesthetics i.v; propofol; oxygen; tension; metabolism; lipid; rabbit;

D O I：

10.1093/bja/81.5.761

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

We have investigated the effect of inhaled oxygen tension on lipid metabolism during propofol infusion. Propofol is supplied as a lipid emulsion containing 10% soybean oil, which is rich in triglycerides (TG). Infused TG are metabolized via three pathways in the liver cell; Krebs cycle, ketogenesis and release as very low density lipoproteins (VLDL) into the blood. For this reason, we measured TG and the products of the three pathways; carbon dioxide, ketone bodies and VLDL. Thirty-two rabbits were anaesthetized under four different conditions: propofol under hyperoxia, normoxia, hypoxia and isoflurane anaesthesia under hyperoxia. Our results indicated that hyperoxia produced more ketone bodies, normoxia more Pa-CO2 and hypoxia more free fatty acids (FFA) and TG compared with the other propofol infusion groups. We conclude that hyperoxia during propofol infusion facilitated fat metabolism through ketogenesis, while normoxia did so via the Krebs cycle. Also, hypoxia suppressed utilization of TG and VLDL production in the liver.

引用

页码：761 / 765

页数：5

共 15 条

[1]

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