Targeted drug delivery in cancer therapy

被引：229

作者：

Vasir, JK

Labhasetwar, V ^{[1
]}

机构：

[1] Coll Pharm, Nebraska Med Ctr 986025, Dept Pharmaceut Sci, Omaha, NE 68198 USA

[2] Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE 68198 USA

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2005年 / 4卷 / 04期

关键词：

nanoparticles; bioconjugates; tumor cells; vasculature; anticancer agents;

D O I：

10.1177/153303460500400405

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapy has been the main modality of treatment for cancer patients; however, its success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue, their intolerable toxicity, development of multi-drug resistance, and the dynamic heterogeneous biology of the growing tumors. Better understanding of tumor biology in recent years and new targeted drug delivery approaches that are being explored using different nanosystems and bioconjugates provide optimism in developing successful cancer therapy. This article reviews the possibilities and challenges for targeted drug delivery in cancer therapy.

引用

页码：363 / 374

页数：12

共 93 条

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