Coding potential of laboratory and clinical strains of human cytomegalovirus

被引：378

作者：

Murphy, E

Yu, D

Grimwood, J

Schmutz, J

Dickson, M

Jarvis, MA

Hahn, G

Nelson, JA

Myers, RM

Shenk, TE ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ USA

[2] Stanford Univ, Sch Med, Dept Genet, Stanford Human Genome Ctr, Stanford, CA 94305 USA

[3] Oregon Hlth & Sci Univ, Vaccine & Gene Therapy Inst, Portland, OR 97239 USA

[4] Oregon Hlth & Sci Univ, Dept Mol Microbiol, Portland, OR 97239 USA

[5] Oregon Hlth & Sci Univ, Dept Immunol, Portland, OR 97239 USA

[6] Univ Munich, Max Von Pettenkofer Inst, Abt Virol, D-80336 Munich, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 25期

关键词：

D O I：

10.1073/pnas.2136652100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Six strains of human cytomegalovirus have been sequenced, including two laboratory strains (AD169 and Towne) that have been extensively passaged in fibroblasts and four clinical isolates that have been passaged to a limited extent in the laboratory (Toledo, FIX, PH, and TR). All of the sequenced viral genomes have been cloned as infectious bacterial artificial chromosomes. A total of 252 ORFs with the potential to encode proteins have been identified that are conserved in all four clinical isolates of the virus. Multiple sequence alignments revealed substantial variation in the amino acid sequences encoded by many of the conserved ORFs.

引用

页码：14976 / 14981

页数：6

共 53 条

[1] THE STRUCTURE OF THE MAJOR IMMEDIATE EARLY GENE OF HUMAN CYTOMEGALO-VIRUS STRAIN AD169 [J].