Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

被引：761

作者：

Marques, Sueli ^{[1
]}

Zeisel, Amit ^{[1
]}

Codeluppi, Simone ^{[1
,2
]}

van Bruggen, David ^{[1
]}

Falcao, Ana Mendanha ^{[1
]}

Xiao, Lin ^{[3
,4
]}

Li, Huiliang ^{[3
]}

Haring, Martin ^{[1
]}

Hochgerner, Hannah ^{[1
]}

Romanov, Roman A. ^{[1
,5
]}

Gyllborg, Daniel ^{[1
]}

Munoz-Manchado, Ana B. ^{[1
]}

La Manno, Gioele ^{[1
]}

Lonnerberg, Peter ^{[1
]}

Floriddia, Elisa M. ^{[1
]}

Rezayee, Fatemah ^{[1
]}

Ernfors, Patrik ^{[1
]}

Arenas, Ernest ^{[1
]}

Hjerling-Leffler, Jens ^{[1
]}

Harkany, Tibor ^{[1
,5
]}

Richardson, William D. ^{[3
]}

Linnarsson, Sten ^{[1
]}

Castelo-Branco, Goncalo ^{[1
]}

机构：

[1] Karolinska Inst, Dept Med Biochem & Biophys, Lab Mol Neurobiol, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden

[3] UCL, Wolfson Inst Biomed Res, Gower St, London WC1E 6BT, England

[4] Second Mil Med Univ, Inst Neurosci, 800 Xiangyin Rd, Shanghai 200433, Peoples R China

[5] Med Univ Vienna, Dept Mol Neurosci, Ctr Brain Res, Vienna, Austria

来源：

SCIENCE | 2016年 / 352卷 / 6291期

基金：

欧洲研究理事会; 瑞典研究理事会; 英国生物技术与生命科学研究理事会; 中国国家自然科学基金; 英国惠康基金;

关键词：

HUMAN INFANCY; MYELIN; TRANSCRIPTOME; NEURONS; CELLS; CNS; DIFFERENTIATION; SEQUENCE; DATABASE; HEALTHY;

D O I：

10.1126/science.aaf6463

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oligodendrocytes have been considered as a functionally homogeneous population in the central nervous system (CNS). We performed single -cell RNA sequencing on 5072 cells of the oligodendrocyte lineage from 10 regions of the mouse juvenile and adult CNS. Thirteen distinct populations were identified, 12 of which represent a continuum from Pdgfra' oligodendrocyte precursor cells (OPCs) to distinct mature oligodendrocytes. Initial stages of differentiation were similar across the juvenile CNS, whereas subsets of mature oligodendrocytes were enriched in specific regions in the adult brain. Newly formed oligodendrocytes were detected in the adult CNS and were responsive to complex motor learning. A second Pdgfra' population, distinct from OPCs, was found along vessels. Our study reveals the dynamics of oligodendrocyte differentiation and maturation, uncoupling them at a transcriptional level and highlighting oligodendrocyte heterogeneity in the CNS.

引用

页码：1326 / 1329

页数：4

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