Molecular determinants of TCR expression and selection

被引：49

作者：

Berg, LJ ^{[1
]}

Kang, JS ^{[1
]}

机构：

[1] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01655 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(00)00209-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The process of T cell development in the thymus is tightly regulated, being dependent on the integration of signals required for thymocyte maturation and survival. Rearrangements, expression and signaling of TCR genes play an indispensable role in this developmental program. Recent advances have provided insights into the molecular mechanisms that regulate TCR repertoire formation at the level of alpha beta versus gamma delta T cell fate and CD4(+) versus CD8(+) lineage determination.

引用

页码：232 / 241

页数：10

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