The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

被引：799

作者：

King, Nicole ^{[1
,2
,3
]}

Westbrook, M. Jody ^{[1
,2
]}

Young, Susan L. ^{[1
,2
]}

Kuo, Alan ^{[4
]}

Abedin, Monika ^{[1
,2
]}

Chapman, Jarrod ^{[1
,2
]}

Fairclough, Stephen ^{[1
,2
]}

Hellsten, Uffe ^{[4
]}

Isogai, Yoh ^{[1
,2
]}

Letunic, Ivica ^{[5
]}

Marr, Michael ^{[6
]}

Pincus, David ^{[7
]}

Putnam, Nicholas ^{[1
,2
]}

Rokas, Antonis ^{[8
]}

Wright, Kevin J. ^{[1
,2
]}

Zuzow, Richard ^{[1
,2
]}

Dirks, William ^{[1
,2
]}

Good, Matthew ^{[7
]}

Goodstein, David ^{[1
,2
]}

Lemons, Derek ^{[9
]}

Li, Wanqing ^{[10
]}

Lyons, Jessica B. ^{[1
,2
]}

Morris, Andrea ^{[11
]}

Nichols, Scott ^{[1
,2
]}

Richter, Daniel J. ^{[1
,2
]}

Salamov, Asaf ^{[4
]}

Bork, Peer ^{[5
]}

Lim, Wendell A. ^{[7
]}

Manning, Gerard ^{[12
]}

Miller, W. Todd ^{[10
]}

McGinnis, William ^{[9
]}

Shapiro, Harris ^{[4
]}

Tjian, Robert ^{[1
,2
]}

Grigoriev, Igor V. ^{[4
]}

Rokhsar, Daniel ^{[1
,2
,4
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Ctr Integrat Genom, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Integrat Biol, Berkeley, CA 94720 USA

[4] Dept Energy Joint Genome Inst, Walnut Creek, CA 94598 USA

[5] European Mol Biol Lab, D-69012 Heidelberg, Germany

[6] Brandeis Univ, Dept Biol, Waltham, MA 02454 USA

[7] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA

[8] Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37235 USA

[9] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

[10] SUNY Stony Brook, Dept Physiol & Biophys, Stony Brook, NY 11794 USA

[11] Univ Michigan, Dept Cellular & Mol Biol, Ann Arbor, MI 48109 USA

[12] Salk Inst Biol Studies, Razavi Newman Bioinformat Ctr, La Jolla, CA 92037 USA

来源：

NATURE | 2008年 / 451卷 / 7180期

关键词：

UNICELLULAR RELATIVES; EVOLUTIONARY ORIGIN; CELL-ADHESION; INSIGHTS; CONSERVATION; ARCHITECTURE; PROTEINS; FAMILY;

D O I：

10.1038/nature06617

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Choanoflagellates are the closest known relatives of metazoans. To discover potential molecular mechanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome of the unicellular choanoflagellate Monosiga brevicollis. The genome contains approximately 9,200 intron- rich genes, including a number that encode cell adhesion and signalling protein domains that are otherwise restricted to metazoans. Here we show that the physical linkages among protein domains often differ between M. brevicollis and metazoans, suggesting that abundant domain shuffling followed the separation of the choanoflagellate and metazoan lineages. The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans.

引用

页码：783 / 788

页数：6

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