Exposure to bisphenol A is associated with recurrent miscarriage

被引：293

作者：

Sugiura-Ogasawara, M ^{[1
]}

Ozaki, Y

Sonta, SI

Makino, T

Suzumori, K

机构：

[1] Nagoya City Univ, Sch Med, Dept Obstet & Gynecol, Mizuho Ku, Nagoya, Aichi 467, Japan

[2] Tokai Univ, Sch Med, Dept Genet, Inst Dev Res,Aichi Human Serv Ctr, Kanagawa 2591100, Japan

[3] Tokai Univ, Sch Med, Dept Obstet & Gynecol, Kanagawa 2591100, Japan

来源：

HUMAN REPRODUCTION | 2005年 / 20卷 / 08期

关键词：

aneuploidy; antinuclear antibody; bisphenol A; embryonic karyotype; recurrent miscarriage;

D O I：

10.1093/humrep/deh888

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

BACKGROUND: Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities. METHODS: Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively. RESULTS: The mean +/- SD values for bisphenol A in patients were 2.59 +/- 5.23ng/ml, significantly higher than the 0.77 +/- 0.38ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage. CONCLUSION: Exposure to bisphenol A is associated with recurrent miscarriage.

引用

页码：2325 / 2329

页数：5

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