Central lead administration induces natriuretic and kaliuretic effects in rats

被引:4
作者
Fregoneze, JB [1 ]
Luz, CP
Sarmento, C
Gonzalez, V
Oliveira, P
Santana, P
Marinho, CA
Castro, L
Nascimento, T
De Paula, S
Lima, AKS
De Oliveira, IR
De Castro-E-Silva, E
机构
[1] Univ Fed Bahia, Inst Biol, Dept Zool, BR-40117011 Salvador, BA, Brazil
[2] Univ Fed Bahia, Hlth Sci Inst, Dept Physiol, BR-40117011 Salvador, BA, Brazil
[3] Univ Fed Bahia, Sch Med, Dept Neuropsychiat, BR-40117011 Salvador, BA, Brazil
关键词
lead; lead intoxication; lead neurotoxicity; brain angiotensin; calcium; calcium channels; losartan; gadolinium; natriuresis; kaliuresis;
D O I
10.1016/S0031-9384(98)00172-3
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
The aim of the present experiments was to discern whether central acute lead injections affect brain control of renal function. Adult Wistar male rats received third-ventricle injections of lead acetate in three different doses (0.03, 0.3, and 3.0 nmol/rat). Lead acetate induced a significant increase in renal excretion of sodium and potassium. Pretreatment with losartan, a selective angiotensin II ATI receptor antagonist (10.8 nmol/rat into the third ventricle 10 min before central lead injection), inhibits lead-induced natriuretic and kaliuretic effects. In addition, pretreatment with gadolinium, a calcium-channel blacker (0.3 nmol/rat into the third ventricle 20 min before central lead administration), reversed the increase in renal excretion of sodium and potassium provoked by central lead administration. Taken together, the data presented here suggest that lead injected into the third ventricle increases renal excretion of sodium and potassium by a mechanism that depends on the functional integrity of central angiotensin II ATI receptors and calcium channels. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:321 / 326
页数:6
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