Homeobox genes and cancer: New OCTaves for an old tune

被引:24
作者
Abate-Shen, C [1 ]
机构
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Med, Piscataway, NJ 08854 USA
[3] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Canc Inst New Jersey, Dept Neurosci, Piscataway, NJ 08854 USA
关键词
D O I
10.1016/S1535-6108(03)00277-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In this issue of Cancer Cell, Gidekel et al. demonstrate that Oct-4, a member of the POU class of homeobox genes, is a critical player in the genesis of testicular germ cell tumors. This study provides further evidence that deregulated expression of homeobox genes, which occurs in many solid tumors, is functionally relevant for carcinogenesis and highlights unique features that distinguish homeobox genes from other cancer-promoting genes.
引用
收藏
页码:329 / 330
页数:2
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