FANCP/SLX4 A Swiss army knife of DNA interstrand crosslink repair

被引：43

作者：

Cybulski, Kelly E. ^{[1
]}

Howlett, Niall G. ^{[1
]}

机构：

[1] Univ Rhode Isl, Dept Cell & Mol Biol, Kingston, RI 02881 USA

来源：

CELL CYCLE | 2011年 / 10卷 / 11期

关键词：

Fanconi anemia; DNA repair; ubiquitin; FANCP/SLX4; DNA interstrand crosslink repair; ANEMIA CORE COMPLEX; STRUCTURE-SPECIFIC NUCLEASES; HOLLIDAY JUNCTION RESOLVASE; NUCLEOTIDE EXCISION-REPAIR; FANCONI-ANEMIA; FANCD2; MONOUBIQUITINATION; PROTEIN; GENE; REPLICATION; IDENTIFICATION;

D O I：

10.4161/cc.10.11.15818

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Fanconi anemia (FA) is a rare genetic disease characterized by congenital abnormalities, bone marrow failure and heightened cancer susceptibility. The FA proteins are known to function in the cellular defense against DNA interstrand crosslinks (ICLs), a process that remains poorly understood. A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C. In this perspective we describe the discovery of FANCP/SLX4 and discuss how these new findings collectively refine our understanding of DNA ICL repair.

引用

页码：1757 / 1763

页数：7

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