Homeostatic regulation of AMPA receptor expression at single hippocampal synapses

被引：124

作者：

Hou, Qingming ^{[1
]}

Zhang, Dawei ^{[1
]}

Jarzylo, Larissa ^{[1
]}

Huganir, Richard L. ^{[2
]}

Man, Heng-Ye ^{[1
]}

机构：

[1] Boston Univ, Dept Biol, Boston, MA 02215 USA

[2] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 02期

关键词：

single synapse; synaptic plasticity; synaptic specificity; Kir; 2.1;

D O I：

10.1073/pnas.0706447105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Homeostatic synaptic response is an important measure in confining neuronal activity within a narrow physiological range. Whether or not homeostatic plasticity demonstrates synapse specificity, a key feature characteristic of Hebbian-type plasticity, is largely unknown. Here, we report that in cultured hippocampal neurons, alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid subtype glutamate receptor (AMPAR) accumulation is increased selectively in chronically inhibited single synapses, whereas the neighboring normal synapses remain unaffected. This synapse-specific homeostatic regulation depends on the disparity of synaptic activity and is mediated by GluR2-lacking AMPARs and PI3-kinase signaling. These results demonstrate the existence of synaptic specificity and the crucial role of AMPAR-gated calcium in homeostatic plasticity in central neurons.

引用

页码：775 / 780

页数：6

共 35 条

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