Neural stem cells: balancing self-renewal with differentiation

被引：310

作者：

Doe, Chris Q. ^{[1
]}

机构：

[1] Univ Oregon, Inst Mol Biol, Inst Neurosci, Howard Hughes Med Inst, Eugene, OR 97403 USA

来源：

DEVELOPMENT | 2008年 / 135卷 / 09期

关键词：

D O I：

10.1242/dev.014977

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem cells are captivating because they have the potential to make multiple cell types yet maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural stem cells have shed light on how stem cells regulate self-renewal versus differentiation and have revealed the proteins, processes and pathways that all converge to regulate neural progenitor self-renewal. If we can better understand how stem cells balance self-renewal versus differentiation, we will significantly advance our knowledge of embryogenesis, cancer biology and brain evolution, as well as the use of stem cells for therapeutic purposes.

引用

页码：1575 / 1587

页数：13

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