Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus

被引：258

作者：

Kreimer, AR

Alberg, AJ

Daniel, R

Gravitt, PE

Viscidi, R

Garrett, ES

Shah, KV

Gillison, ML

机构：

[1] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mol Microbiol & Immunol, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Dept Biostat, Baltimore, MD 21231 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2004年 / 189卷 / 04期

关键词：

D O I：

10.1086/381504

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevalence and risk factors for oral human papillomavirus (HPV) infection are unknown, despite evidence for an etiological role for HPV in oral cancers. Oral samples from human immunodeficiency virus (HIV)-seronegative (n = 396) and HIV-seropositive (n = 190) adults were tested for HPV DNA. High-risk HPV infections were present in 2.1% of tonsil and 6.3% of oral-rinse specimens. The prevalence of oral high-risk HPV infection was greater in HIV-seropositive individuals (13.7% vs. 4.5%; P < .001). In multiple logistic regression, odds of oral HPV infection increased with age, male sex, and herpes simplex virus (HSV)-2 seropositivity in HIV-seronegative individuals and with CD4 cell count <200 cells/mL, HSV-2 seropositivity, oral mucosal abnormalities, and >1 oral sex partner during the previous year (odds ratio, 12.8; 95% confidence interval, 3.1-52.7) among HIV-seropositive individuals. HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection.

引用

页码：686 / 698

页数：13

共 79 条

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