MHC class I and class II structures

被引：61

作者：

Jones, EY

机构：

[1] Laboratory of Molecular Biophysics, Rex Richards Bldg., S. Parks Rd., O., Oxford

来源：

CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(97)80162-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The basic structures of MHC class I and class II molecules are now well established. Over the past twelve months structural data on MHC class I molecules have provided details of the peptide binding groove for a number of alleles and have elaborated the mechanisms that allow binding of a range of peptides. Recent MHC class II structures have illustrated the mode of peptide binding both in mature complexes and in the MHC class II complex with a fragment of invariant chain (CLIP) during maturation.

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页码：75 / 79

页数：5

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