Effects of barium on stimulus-induced changes in [K+]o and field potentials in dentate gyrus and area CA1 of human epileptic hippocampus

被引：40

作者：

Gabriel, S

Kivi, A

Kovacs, R

Lehmann, TN

Lanksch, WR

Meencke, HJ

Heinemann, U

机构：

[1] Humboldt Univ, Klinikum Charite, Inst Physiol, D-10117 Berlin, Germany

[2] Humboldt Univ, Neurosurg Clin, D-10117 Berlin, Germany

[3] Konigin Elisabeth Hosp Herzberge, Epilepsy Ctr Berlin, Berlin, Germany

来源：

NEUROSCIENCE LETTERS | 1998年 / 249卷 / 2-3期

关键词：

hippocampal sclerosis; temporal lobe epilepsy; potassium regulation; slice;

D O I：

10.1016/S0304-3940(98)00420-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of barium on stimulus-induced rises in [K+](o) were studied in the dentate gyrus (DG) and area CA1 of human hippocampal slices. Rises in [K+](o) elicited by repetitive stimulation of the hilus, stratum moleculare, alveus, or stratum radiatum were dependent on stimulus intensity and frequency. Barium augmented rises in [K+](o) in the DG by about 120% but failed to do so in area CA1. In both DG and area CA1 barium had no effects on population spikes whereas stimulus-induced slow field potentials were reduced. Since barium interferes with K+ uptake and redistribution by blocking leak conductances and inwardly-rectifying currents in astrocytes, our findings suggest that glial cells in the sclerotic hippocampal area CA1 may contribute less to K+ regulation. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：91 / 94

页数：4

共 18 条

[1] ION ACTIVITIES AND POTASSIUM UPTAKE MECHANISMS OF GLIAL-CELLS IN GUINEA-PIG OLFACTORY CORTEX SLICES [J].