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Kzfl -: a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis

被引：20
作者：
Bellefroid, EJ
Sahin, M
Poncelet, DA
Rivière, M
Bourguignon, C
Martial, JA
Morris, PL
Pieler, T
Szpirer, C
Ward, DC
机构：
[1] Yale Univ, Sch Med, Dept Genet & Mol Biophys & Biochem, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Neurobiol Sect, New Haven, CT 06510 USA
[3] Univ Liege, Inst Chim, Lab Cent Biol Mol & Genie Genet, B-4000 Sart, Belgium
[4] Free Univ Brussels, Dept Biol Mol, B-1640 Rhode St Genese, Belgium
[5] Populat Council, New York, NY 10021 USA
[6] Rockefeller Univ, New York, NY 10021 USA
[7] Univ Gottingen, Inst Biochem & Mol Zellbiol, D-37073 Gottingen, Germany
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1398卷 / 03期
关键词：
cDNA; zinc finger protein; KRAB; spermatogenesis;
D O I：
10.1016/S0167-4781(98)00057-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two novel KRAB (Kruppel associated box) type zinc finger protein encoding cDNAs, named Kzf1 and Kzf2 (Kzf for KRAB zinc finger), were identified by screening of a rat embryonic brain cDNA library with a human ZNF91 KRAB probe. Kzf1 and Kzf2 encode proteins with an amino-terminal KRAB domain and a carboxy terminal zinc finger cluster containing 9 and 13 zinc finger units, respectively. While Ksf2 appears to be ubiquitously expressed, Kzf1 is preferentially expressed in the testis, Within the testis, Krf1 mRNA is restricted to germ cells. The Kzf1 protein exhibits DNA binding activity and its KRAB domain can function as a repressor module in transcription, Using somatic cell hybrid analysis, the Kzf1 gene was mapped to chromosome 6. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：321 / 329
页数：9
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