How Antibiotics Stewardship Can Be Safely Implemented in Patients with Septic Shock?

被引：3

作者：

de Montmollin, Etienne ^{[1
,2
]}

Timsit, Jean-Francois ^{[1
,2
]}

机构：

[1] Bichat Claude Bernard Univ Hosp, AP HP, Med & Infect Dis Intens Care Unit, Paris, France

[2] Univ Paris, INSERM IAME UMR 1137, Sorbonne Paris Cite, Paris, France

来源：

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE | 2021年 / 42卷 / 05期

关键词：

septic shock; sepsis; antimicrobials; pharmacokinetics; antimicrobial stewardship; VENTILATOR-ASSOCIATED PNEUMONIA; CRITICALLY-ILL PATIENTS; INTENSIVE-CARE-UNIT; BETA-LACTAM ANTIBIOTICS; ANTIMICROBIAL THERAPY; SEVERE SEPSIS; CRITICAL DETERMINANT; SURVIVING SEPSIS; RISK-FACTORS; DURATION;

D O I：

10.1055/s-0041-1733987

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

In critically ill patients with sepsis and septic shock, the need for prompt and adequate antibiotic therapy is balanced by the risk of excessive antibiotic exposure that leads to emergence of multidrug-resistant pathogens. As such, antibiotic stewardship programs propose a set of operating rules from antibiotic treatment initiation to de-escalation and finally cessation. In this review, we will describe the rationale for early antibiotic treatment in septic patients, how to optimize initial antibiotic treatment, rules for early treatment discontinuation in pathogen-negative sepsis, and optimal duration of antimicrobial therapy.

引用

页码：689 / 697

页数：9

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