Flavonoids and a naphthopyranone from Eriocaulon ligulatum and their mutagenic activity

被引：12

作者：

da Silva, Marcelo Aparecido ^{[1
]}

Siqueira Oliveira, Ana Paula ^{[2
]}

Sannomiya, Miriam ^{[1
]}

Sano, Paulo Takeo ^{[3
]}

Varanda, Eliana Aparecida ^{[2
]}

Vilegas, Wagner ^{[1
]}

dos Santos, Lourdes Campaner ^{[1
]}

机构：

[1] Univ Estadual Paulista, Inst Quim Araraquara, Dept Organ Chem, BR-14801970 Sao Paulo, Brazil

[2] Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Biol, BR-14801902 Sao Paulo, Brazil

[3] Univ Sao Paulo, Inst Biociencias, Dept Bot, BR-05422097 Sao Paulo, Brazil

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2007年 / 55卷 / 11期

关键词：

Eriocaulon ligulatum; Eriocaulaceae; naphthopyranone; flavonoid; Ames test; high speed counter-current chromatography;

D O I：

10.1248/cpb.55.1635

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A new acylated flavonoid, 6,4'-dimethoxyquereetin-3-O-beta-D-6 ''[3,4,5-trihydroxy (E)-cinnamoyl]glucopyranoside, and a naphthopyranone dimer, named eriocauline, together with 2 other known flavonoids, 6-methoxyapigenin-7-O-beta-D-glucopyranoside and 6-methoxyapigenin-7-O-beta-D-allopyranoside, have been isolated from the capitulae of Eriocaulon ligulatum. The compounds were identified using spectroscopic methods (HR-ESI-MS, and 1-D and 2-D NMR). The methanol extract exhibited mutagenic activity in the Salmonella/microsome assay, in strains TA100, TA97a and TA102 and for dichloromethane extract tested in strain TA98.

引用

页码：1635 / 1639

页数：5

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