Antituberculosis Agents and an Inhibitor of the para-Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds

被引：37

作者：

Wang, Jun-Feng ^{[1
,3
]}

Dai, Huan-Qin ^{[2
]}

Wei, Yu-Ling ^{[4
]}

Zhu, Hua-Jie ^{[1
]}

Yan, Yong-Ming ^{[1
]}

Wang, Yue-Hu ^{[1
]}

Long, Chun-Lin ^{[1
]}

Zhong, Hui-Min ^{[3
]}

Zhang, Li-Xin ^{[2
]}

Cheng, Yong-Xian ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, Beijing, Peoples R China

[3] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao, Peoples R China

[4] Yunnan Acad Tobacco Sci, Kunming, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2010年 / 7卷 / 08期

基金：

中国国家自然科学基金;

关键词：

MULTIDRUG-RESISTANT; FLAVONOLIGNANS; TUBERCULOSIS;

D O I：

10.1002/cbdv.201000072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Investigation on the extracts of Hydnocarpus anthelminthica seeds led to the isolation of three new compounds, anthelminthieins A C (1-3, resp). and two known ones, namely chaulmoogric acid (4) and ethyl chaulmoograte (5) Their structures were determined mainly by using spectroscopic techniques The absolute configuration at the cyclopentenyl moiety of compound 2 was rationalized by quantum calculations Base hydrolysis, followed by optical-rotation comparison, allowed assignment of the configuration of chaulmoogric-acid moiety of compounds 3 and 5 Biological assays revealed that compounds 1-5 significantly inhibit Mycobacterium tuberculosis(MTB) growth with MIC values of 5 54. 16 70, 4 38, 9 82, and 16 80 mu M, respectively Compound 3 was found to inhibit the pathway between chorismate and para-aminobenzoic acid (pAba) with a MIC value of 11 3 mu m, representing a new example of pAba inhibitor isolated from a natural source All compounds were not toxic to Candida albicans SC5314 at a concentration up to 100 mu m

引用

页码：2046 / 2053

页数：8

共 23 条

[1]

Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection [J].