Activation of a unique population of CD8+ T cells by intestinal epithelial cells

被引：27

作者：

Allez, M ^{[1
]}

Brimnes, J ^{[1
]}

Shao, L ^{[1
]}

Dotan, I ^{[1
]}

Nakazawa, A ^{[1
]}

Mayer, L ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Immunobiol Ctr, New York, NY 10029 USA

来源：

ORAL TOLERANCE: NEW INSIGHTS AND PROSPECTS FOR CLINICAL APPLICATION | 2004年 / 1029卷

关键词：

intestinal epithelial cell; T regulatory cell; CD8; CD1D; gp180;

D O I：

10.1196/annals.1309.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intestinal epithelial cells may play a role in the regulation of immune responses toward luminal antigens. We show that a subset of CD8(+) T cells undergoes oligoclonal expansion in the intestinal mucosa, probably through interaction with a unique complex expressed on epithelial cells, formed by a CEA subfamily member (gp180) and CD1d. This subset, which is regulatory in vitro, may play a role in the control of intestinal immune responses toward luminal antigens. A lack of expansion of these CD8(+) regulatory T cells, probably related to the defective expression of the gp180/CD1d complex, is observed in inflammatory bowel disease.

引用

页码：22 / 35

页数：14

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