Early changes in quasispecies repertoire in HIV-infected infants: Correlation with disease progression

被引:14
作者
Essajee, SM [1 ]
Pollack, H [1 ]
Rochford, G [1 ]
Oransky, I [1 ]
Krasinski, K [1 ]
Borkowsky, W [1 ]
机构
[1] NYU, Med Ctr, Dept Pediat Infect Dis, New York, NY 10016 USA
关键词
D O I
10.1089/088922200750054675
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The evolution of HIV-1 quasispecies in patients during the first year of life was investigated in 10 vertically infected infants, using heteroduplex analysis of the V3-V5 region of env. Four subjects, who showed little viral evolution during the period of the study, had rapid progression of disease and early loss of CD4(+) cells. The remaining six subjects, who were slow progressors, evolved new viral variants within 6 months, and in one case by 1 month of age. Of the four patients who were PCR positive at birth, one was infected with multiple HIV-1 variants. These results show that in HIV-infected children, multiple variants may initiate infection and early quasispecies diversification is associated with a favorable clinical outcome.
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收藏
页码:1949 / 1957
页数:9
相关论文
共 41 条
[1]   INCUBATION PERIODS FOR PEDIATRIC AIDS PATIENTS [J].
AUGER, I ;
THOMAS, P ;
DEGRUTTOLA, V ;
MORSE, D ;
MOORE, D ;
WILLIAMS, R ;
TRUMAN, B ;
LAWRENCE, CE .
NATURE, 1988, 336 (6199) :575-577
[2]   Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus [J].
Borrow, P ;
Lewicki, H ;
Wei, XP ;
Horwitz, MS ;
Peffer, N ;
Meyers, H ;
Nelson, JA ;
Gairin, JE ;
Hahn, BH ;
Oldstone, MBA ;
Shaw, GM .
NATURE MEDICINE, 1997, 3 (02) :205-211
[3]   ANALYSIS OF ENVELOPE SEQUENCE VARIANTS SUGGESTS MULTIPLE MECHANISMS OF MOTHER-TO-CHILD TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].
BRIANT, L ;
WADE, CM ;
PEUL, J ;
BROWN, AJL ;
GUYADER, M .
JOURNAL OF VIROLOGY, 1995, 69 (06) :3778-3788
[4]   CYTOTOXIC LYMPHOCYTE-T RESPONSES IN THE PERIPHERAL-BLOOD OF CHILDREN BORN TO HUMAN IMMUNODEFICIENCY VIRUS-1-INFECTED MOTHERS [J].
CHEYNIER, R ;
LANGLADEDEMOYEN, P ;
MARESCOT, MR ;
BLANCHE, S ;
BLONDIN, G ;
WAINHOBSON, S ;
GRISCELLI, C ;
VILMER, E ;
PLATA, F .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (09) :2211-2217
[5]   HIV POPULATION-DYNAMICS IN-VIVO - IMPLICATIONS FOR GENETIC-VARIATION, PATHOGENESIS, AND THERAPY [J].
COFFIN, JM .
SCIENCE, 1995, 267 (5197) :483-489
[6]   INCREASED VIRAL BURDEN AND CYTOPATHICITY CORRELATE TEMPORALLY WITH CD4+ T-LYMPHOCYTE DECLINE AND CLINICAL PROGRESSION IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE 1-INFECTED INDIVIDUALS [J].
CONNOR, RI ;
MOHRI, H ;
CAO, YZ ;
HO, DD .
JOURNAL OF VIROLOGY, 1993, 67 (04) :1772-1777
[7]   Mother-to-infant transmission of human immunodeficiency virus type 1 involving five envelope sequence subtypes [J].
Contag, CH ;
Ehrnst, A ;
Duda, J ;
Bohlin, AB ;
Lindgren, S ;
Learn, GH ;
Mullins, JI .
JOURNAL OF VIROLOGY, 1997, 71 (02) :1292-1300
[8]   GENETIC-RELATIONSHIPS DETERMINED BY A DNA HETERODUPLEX MOBILITY ASSAY - ANALYSIS OF HIV-1 ENV GENES [J].
DELWART, EL ;
SHPAER, EG ;
LOUWAGIE, J ;
MCCUTCHAN, FE ;
GREZ, M ;
RUBSAMENWAIGMANN, H ;
MULLINS, JI .
SCIENCE, 1993, 262 (5137) :1257-1261
[9]   Slower evolution of human immunodeficiency virus type I quasispecies during progression to AIDS [J].
Delwart, EL ;
Pan, H ;
Sheppard, HW ;
Wolpert, D ;
Neumann, AU ;
Korber, B ;
Mullins, JI .
JOURNAL OF VIROLOGY, 1997, 71 (10) :7498-7508
[10]   Rapid, transient changes at the env LOCUS of plasma human immunodeficiency virus type 1 populations during the emergence of protease inhibitor resistance [J].
Delwart, EL ;
Pan, H ;
Neumann, A ;
Markowitz, M .
JOURNAL OF VIROLOGY, 1998, 72 (03) :2416-2421