Association between BDNF Val66Met genotype and episodic memory

被引：150

作者：

Dempster, E ^{[1
]}

Toulopoulou, T ^{[1
]}

McDonald, C ^{[1
]}

Bramon, E ^{[1
]}

Walshe, M ^{[1
]}

Filbey, F ^{[1
]}

Wickham, H ^{[1
]}

Sham, PC ^{[1
]}

Murray, RM ^{[1
]}

Collier, DA ^{[1
]}

机构：

[1] Inst Psychiat, Mol Genet Sect, Div Psychol Med, London SE5 8AF, England

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2005年 / 134B卷 / 01期

关键词：

D O I：

10.1002/ajmg.b.30150

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The val(66) met polymorphism of brain derived neurotrophic factor (BDNF) has been associated with variability in episodic memory [Egan et al., 2003]. In an attempt to replicate this finding, we genotyped 206 individuals (92 affected with schizophrenia or a related disorder and 114 unaffected relatives) from the Maudsley Family Study for the BDNF val(66) met polymorphism. We analyzed the effect of this polymorphism on episodic memory using the Wechsler Memory Scale, revised version (WMS-R) by regression analysis between the WMS delayed score of logical memory and genotype (corrected for age, sex, and IQ). We found the met(66) allele conferred a lower score on the WMS delayed measure (R-2=0.014 P=0.09), which was not significant. When cases and unaffected relatives were analyzed separately, met66 was associated with a lower score on the WMS delayed measure in the relatives only (R-2=0.077 P=0.01), which is consistent with previous findings. C 2005 Wiley-Liss, Inc.

引用

页码：73 / 75

页数：3

共 22 条

[1] Borghesani PR, 2002, DEVELOPMENT, V129, P1435
[2] Pedigree disequilibrium tests for multilocus haplotypes
Dudbridge, F
[J]. GENETIC EPIDEMIOLOGY, 2003, 25 (02) : 115 - 121
[3] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Egan, MF
Kojima, M
Callicott, JH
Goldberg, TE
Kolachana, BS
Bertolino, A
Zaitsev, E
Gold, B
Goldman, D
Dean, M
Lu, B
Weinberger, DR
[J]. CELL, 2003, 112 (02) : 257 - 269
[4] ENDICOTT J, 1978, ARCH GEN PSYCHIAT, V35, P837
[5] The Maudsley family study .2. Endogenous event-related potentials in familial schizophrenia
Frangou, S
Sharma, T
Alarcon, G
Sigmudsson, T
Takei, N
Binnie, C
Murray, RM
[J]. SCHIZOPHRENIA RESEARCH, 1997, 23 (01) : 45 - 53
[6] Minor physical anomalies in familial and sporadic schizophrenia: the Maudsley family study
Griffiths, TD
Sigmundsson, T
Takei, N
Frangou, S
Birkett, PB
Sharma, T
Reveley, AM
Murray, RM
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1998, 64 (01) : 56 - 60
[7] Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder
Hall, D
Dhilla, A
Charalambous, A
Gogos, JA
Karayiorgou, M
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (02) : 370 - 376
[8] Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
Hariri, AR
Goldberg, TE
Mattay, VS
Kolachana, BS
Callicott, JH
Egan, MF
Weinberger, DR
[J]. JOURNAL OF NEUROSCIENCE, 2003, 23 (17) : 6690 - 6694
[9] Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortex
Itami, C
Mizuno, K
Kohno, T
Nakamura, S
[J]. BRAIN RESEARCH, 2000, 857 (1-2) : 141 - 150
[10] Brain volumes in familial and non-familial schizophrenic probands and their unaffected relatives
McDonald, C
Grech, A
Touopoulou, T
Schulze, K
Chapple, B
Sham, P
Walshe, M
Sharma, T
Sigmundsson, T
Chitnis, X
Murray, RM
[J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 114 (06): : 616 - 625

← 1 2 3 →