Importance and detection of virus reservoirs and compartments of HIV infection

被引：42

作者：

Nickle, DC

Shriner, D

Mittler, JE

Frenkel, LM

Mullins, JI ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98105 USA

[2] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98105 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2003年 / 6卷 / 04期

关键词：

D O I：

10.1016/S1369-5274(03)00096-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Current therapies for treating HIV-1 infection are capable of suppressing virus load in blood to undetectable levels, and result in marked clinical improvement. Despite this suppression, HIV-1 infection persists and virus load quickly rebounds when therapy is interrupted. The origin of the rebounding virus is unknown, but is thought to result from continuing viral replication in anatomic or cellular compartments, and the release of virus from latent infection in reservoirs.

引用

收藏

页码：410 / 416

页数：7

相关论文

共 33 条

[1]

BEERLI P, 2000, COMPUTATIONAL EVOLUT, P217

[2] The challenge of viral reservoirs in HIV-1 infection [J].

Blankson, JN ;

Persaud, D ;

Siliciano, RF .

ANNUAL REVIEW OF MEDICINE, 2002, 53 :557-593

[3] The origin of acquired immune deficiency syndrome: Darwinian or Lamarckian? [J].

Burr, T ;

Hyman, JM ;

Myers, G .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 2001, 356 (1410) :877-887

[4] Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy [J].

Chun, TW ;

Davey, RT ;

Ostrowski, M ;

Justement, JS ;

Engel, D ;

Mullins, JI ;

Fauci, AS .

NATURE MEDICINE, 2000, 6 (07) :757-761

[5] Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection [J].

Chun, TW ;

Engel, D ;

Berrey, MM ;

Shea, T ;

Corey, L ;

Fauci, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8869-8873

[6] The number of HIV DNA-infected mononuclear cells is reduced under HAART plus recombinant IL-2 [J].

Dianzani, F ;

Antonelli, G ;

Aiuti, F ;

Turriziani, O ;

Riva, E ;

Capobianchi, MR ;

Pandolfi, F ;

D'Offizi, G .

ANTIVIRAL RESEARCH, 2000, 45 (02) :95-99

[7] Reconstructing genealogies of serial samples under the assumption of a molecular clock using serial-sample UPGMA [J].

Drummond, A ;

Rodrigo, AG .

MOLECULAR BIOLOGY AND EVOLUTION, 2000, 17 (12) :1807-1815

[8] Genetic characterization of rebounding human immunodeficiency virus type 1 in plasma during multiple interruptions of highly active antiretroviral therapy [J].

Dybul, M ;

Daucher, M ;

Jensen, MA ;

Hallahan, CW ;

Chun, TW ;

Belson, M ;

Hidalgo, B ;

Nickle, DC ;

Yoder, C ;

Metcalf, JA ;

Davey, RT ;

Ehler, L ;

Kress-Rock, D ;

Nies-Kraske, E ;

Liu, SY ;

Mullins, JI ;

Fauci, AS .

JOURNAL OF VIROLOGY, 2003, 77 (05) :3229-3237

[9] Pilot study of the effects of intermittent interleukin-2 on human immunodeficiency virus (HIV)-specific immune responses in patients treated during recently acquired HIV infection [J].

Dybul, M ;

Hidalgo, B ;

Chun, TW ;

Belson, M ;

Migueles, SA ;

Justement, JS ;

Herpin, B ;

Perry, C ;

Hallahan, CW ;

Davey, RT ;

Metcalf, JA ;

Connors, M ;

Fauci, AS .

JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (01) :61-68

[10]

Felsenstein J., 1993, PHYLIP PHYLOGENY INF

← 1 2 3 4 →