Retrograde traffic in the biosynthetic-secretory route: pathways and machinery

被引:67
作者
Sannerud, R
Saraste, J
Goud, B
机构
[1] Univ Bergen, Dept Anat & Cell Biol, N-5009 Bergen, Norway
[2] Inst Curie, CNRS, UMR 144, F-75248 Paris 05, France
关键词
D O I
10.1016/S0955-0674(03)00077-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In the secretory pathway, the forward (anterograde) membrane flow is compensated by retrograde transport of proteins and lipids. Membrane recycling is required for the maintenance of organelle homeostasis and the re-use of components of the transport machineries for the generation of new transport intermediates. However, the molecular mechanisms and other cellular functions of retrograde traffic are still poorly understood. In recent years, a multitude of protein factors that function in the secretory pathway have been discovered, most of them originally suggested to play a role in forward trafficking. However, in many cases subsequent studies have revealed that these proteins participate (also) in retrograde traffic. It is likely that this shift will continue, reflecting the fact that the two pathways are intimately connected.
引用
收藏
页码:438 / 445
页数:8
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