Therapeutic strategies of diabetic nephropathy: recent progress and future perspectives

被引：140

作者：

Lv, Meng ^{[1
]}

Chen, Zhuo ^{[1
]}

Hu, Gaoyun ^{[1
]}

Li, Qianbin ^{[1
]}

机构：

[1] Cent S Univ, Sch Pharmaceut Sci, Dept Med Chem, Changsha 410013, Hunan, Peoples R China

来源：

DRUG DISCOVERY TODAY | 2015年 / 20卷 / 03期

关键词：

ALDOSE REDUCTASE INHIBITOR; PROTEIN-KINASE-C; CHRONIC KIDNEY-DISEASE; BLOOD-PRESSURE CONTROL; GROWTH-FACTOR-BETA; NF-KAPPA-B; NADPH OXIDASE; OXIDATIVE STRESS; TGF-BETA; TUBULOINTERSTITIAL FIBROSIS;

D O I：

10.1016/j.drudis.2014.10.007

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Diabetic nephropathy (DN) is one of the most common complications of diabetes with high mortality rates worldwide. The treatment of DN has posed a formidable challenge to the scientific community. Simple control of risk factors has been insufficient to cope with the progression of DN. During the process of anti-DN drug discovery, multiple pathogeneses such as oxidative stress, inflammation and fibrosis should all be considered. In this review, the pathogenesis of DN is summarized. The major context focuses on a few small molecules toward the pathogenesis available in animal models and clinical trials for the treatment of DN. The perspectives of novel anti-DN agents and the future directions for the prevention of DN are discussed.

引用

页码：332 / 346

页数：15

共 128 条

[1]

Phase 1 Study of Anti-CTGF Monoclonal Antibody in Patients with Diabetes and Microalbuminuria [J].

Adler, Sharon G. ;

Schwartz, Sherwyn ;

Williams, Mark E. ;

Arauz-Pacheco, Carlos ;

Bolton, Warren K. ;

Lee, Tyson ;

Li, Dongxia ;

Neff, Thomas B. ;

Urquilla, Pedro R. ;

Sewell, K. Lea .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 5 (08) :1420-1428

[2]

Antioxidant and radical scavenging properties of curcumin [J].

Ak, Tuba ;

Gulcin, Ilhami .

CHEMICO-BIOLOGICAL INTERACTIONS, 2008, 174 (01) :27-37

[3]

Lipid-lowering treatment and inflammatory mediators in diabetes and chronic kidney disease [J].

Almquist, Tora ;

Jacobson, Stefan H. ;

Mobarrez, Fariborz ;

Nasman, Per ;

Hjemdahl, Paul .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2014, 44 (03) :276-284

[4]

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease [J].

Altenhofer, Sebastian ;

Kleikers, Pamela W. M. ;

Radermacher, Kim A. ;

Scheurer, Peter ;

Hermans, J. J. Rob ;

Schiffers, Paul ;

Ho, Heidi ;

Wingler, Kirstin ;

Schmidt, Harald H. H. W. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2012, 69 (14) :2327-2343

[5]

Reactive oxygen species: Metabolism, oxidative stress, and signal transduction [J].

Apel, K ;

Hirt, H .

ANNUAL REVIEW OF PLANT BIOLOGY, 2004, 55 :373-399

[6]

Effects of NADPH oxidase inhibitor in diabetic nephropathy [J].

Asaba, K ;

Tojo, A ;

Onozato, ML ;

Goto, A ;

Quinn, MT ;

Fujita, T ;

Wilcox, CS .

KIDNEY INTERNATIONAL, 2005, 67 (05) :1890-1898

[7]

Double-edged action of SOD mimetic in diabetic nephropathy [J].

Asaba, Kensuke ;

Tojo, Akihiro ;

Onozato, Maristela Lika ;

Goto, Atsuo ;

Fujita, Toshiro .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2007, 49 (01) :13-19

[8]

Diabetic kidney disease: act now or pay later [J].

Atkins, Robert C. ;

Zimmet, Paul .

KIDNEY INTERNATIONAL, 2010, 77 (05) :375-377

[9]

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial [J].

Baigent, Colin ;

Landray, Martin J. ;

Reith, Christina ;

Emberson, Jonathan ;

Wheeler, David C. ;

Tomson, Charles ;

Wanner, Christoph ;

Krane, Vera ;

Cass, Alan ;

Craig, Jonathan ;

Neal, Bruce ;

Jiang, Lixin ;

Hooi, Lai Seong ;

Levin, Adeera ;

Agodoa, Lawrence ;

Gaziano, Mike ;

Kasiske, Bertram ;

Walker, Robert ;

Massy, Ziad A. ;

Feldt-Rasmussen, Bo ;

Krairittichai, Udom ;

Ophascharoensuk, Vuddidhej ;

Fellstrom, Bengt ;

Holdaas, Hallvard ;

Tesar, Vladimir ;

Wiecek, Andrzej ;

Grobbee, Diederick ;

de Zeeuw, Dick ;

Gronhagen-Riska, Carola ;

Dasgupta, Tanaji ;

Lewis, David ;

Herrington, William ;

Mafham, Marion ;

Majoni, William ;

Wallendszus, Karl ;

Grimm, Richard ;

Pedersen, Terje ;

Tobert, Jonathan ;

Armitage, Jane ;

Baxter, Alex ;

Bray, Christopher ;

Chen, Yiping ;

Chen, Zhengming ;

Hill, Michael ;

Knott, Carol ;

Parish, Sarah ;

Simpson, David ;

Sleight, Peter ;

Young, Alan ;

Collins, Rory .

LANCET, 2011, 377 (9784) :2181-2192

[10]

NF-κB in Renal Inflammation [J].

Belen Sanz, Ana ;

Dolores Sanchez-Nino, Maria ;

Mario Ramos, Adrian ;

Antonio Moreno, Juan ;

Santamaria, Beatriz ;

Ruiz-Ortega, Marta ;

Egido, Jesus ;

Ortiz, Alberto .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (08) :1254-1262

← 1 2 3 4 5 6 7 8 9 10 →