Differential signaling by CpG DNA in DCs and B cells: not just TLR9

被引：90

作者：

Verthelyi, D

Zeuner, RA

机构：

[1] US FDA, Ctr Biol Evaluat & Res, Div Therapeut Proteins, Bethesda, MD 20892 USA

[2] Univ Kiel, Klinikum Schleswig Holstein, Dept Med 2, D-24116 Kiel, Germany

来源：

TRENDS IN IMMUNOLOGY | 2003年 / 24卷 / 10期

关键词：

D O I：

10.1016/S1471-4906(03)00243-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CpG-containing oligodeoxynucleotides (CpG ODNs) act on Toll-like receptor 9 (TLR9) that is expressed on B cells and plasmacytoid dendritic cells (pDCs) to stimulate the innate immune system, however, different types of CpG ODNs induce distinct responses. Recent papers suggest some CpG ODNs could require a second receptor or cofactor to signal. The different signaling complexes assembled might impact on the affinity with which CpG ODNs signal to TLR9 or activate additional pathways that lead to distinct immune responses.

引用

页码：519 / 522

页数：4

共 27 条

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