A large pool of releasable vesicles in a cortical glutamatergic synapse

被引：135

作者：

Hallermann, S ^{[1
]}

Pawlu, C ^{[1
]}

Jonas, P ^{[1
]}

Heckmann, M ^{[1
]}

机构：

[1] Univ Freiburg, Inst Physiol, D-79104 Freiburg, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 15期

关键词：

D O I：

10.1073/pnas.1432836100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of approximate to1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular "maxipool." Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse.

引用

页码：8975 / 8980

页数：6

共 59 条

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