Midbrain circuits for defensive behaviour

被引：545

作者：

Tovote, Philip ^{[1
]}

Esposito, Maria Soledad ^{[1
,2
]}

Botta, Paolo ^{[1
,5
]}

Haudun, Fabrice C. ^{[3
]}

Fadok, Jonathan P. ^{[1
]}

Markovic, Milica ^{[1
]}

Wolff, Steffen B. E. ^{[1
,6
]}

Ramakrishnan, Charu ^{[4
]}

Fenno, Lief ^{[4
]}

Deisseroth, Karl ^{[4
]}

Herry, Cyril ^{[3
]}

Arber, Silvia ^{[1
,2
]}

Luthi, Andreas ^{[1
]}

机构：

[1] Friedrich Miescher Inst Biomed Res, Maulbeerstr 66, CH-4058 Basel, Switzerland

[2] Univ Basel, Dept Cell Biol, Biozentrum, CH-4056 Basel, Switzerland

[3] INSERM, Neuroctr Magendie, U862, 146 Rue Leo Saignat, F-33077 Bordeaux, France

[4] Stanford Univ, 318 Campus Dr West,Clark Ctr W080, Stanford, CA 94305 USA

[5] Champalimaud Ctr Unknown, Ave Brasilia, P-1400038 Lisbon, Portugal

[6] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA

来源：

NATURE | 2016年 / 534卷 / 7606期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

VENTROLATERAL PERIAQUEDUCTAL GRAY; CONTEXTUAL CONDITIONED FEAR; AMINO-ACID MICROINJECTION; NEURONAL ORGANIZATION; IN-VIVO; ANXIETY; RAT; AMYGDALA; NUCLEUS; PROJECTIONS;

D O I：

10.1038/nature17996

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Survival in threatening situations depends on the selection and rapid execution of an appropriate active or passive defensive response, yet the underlying brain circuitry is not understood. Here we use circuit-based optogenetic, in vivo and in vitro electrophysiological, and neuroanatomical tracing methods to define midbrain periaqueductal grey circuits for specific defensive behaviours. We identify an inhibitory pathway from the central nucleus of the amygdala to the ventrolateral periaqueductal grey that produces freezing by disinhibition of ventrolateral periaqueductal grey excitatory outputs to pre-motor targets in the magnocellular nucleus of the medulla. In addition, we provide evidence for anatomical and functional interaction of this freezing pathway with long-range and local circuits mediating flight. Our data define the neuronal circuitry underlying the execution of freezing, an evolutionarily conserved defensive behaviour, which is expressed by many species including fish, rodents and primates. In humans, dysregulation of this 'survival circuit' has been implicated in anxiety-related disorders.

引用

页码：206 / +

页数：17

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An X, 1998, J COMP NEUROL, V401, P455

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A Framework for Studying Emotions across Species [J].