Molecular profiling of breast cancer: portraits but not physiognomy

被引：31

作者：

Brenton, JD

Aparicio, SAJR

Caldas, C

机构：

[1] Princess Margaret Hosp, Ontario Canc Inst, Dept Med Oncol & Hematol, Toronto, ON M5G 2M9, Canada

[2] Univ Cambridge, Wellcome Trust Ctr Mol Mech Dis, Cambridge Inst Med Res, Cambridge, England

[3] Univ Cambridge, Dept Oncol, Cambridge, England

来源：

BREAST CANCER RESEARCH | 2001年 / 3卷 / 02期

关键词：

breast cancer; cDNA microarray; hierarchical clustering; molecular profiling;

D O I：

10.1186/bcr274

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Breast cancers differ in response to treatment and may have a divergent clinical course despite having a similar histopathological appearance. New technology using DNA microarrays provides a systematic method to identify key markers for prognosis and treatment response by profiling thousands of genes expressed in a single cancer. Microarray profiling of 38 invasive breast cancers now confirms striking molecular differences between ductal carcinoma specimens and suggests a new classification for oestrogen-receptor negative breast cancer. Future approaches will need to include methods for high-throughput clinical validation and the ability to analyze microscopic samples.

引用

页码：77 / 80

页数：4

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