Dynamic multivalent lactosides displayed on cyclodextrin beads dangling from polymer strings

被引:46
作者
Nelson, A
Stoddart, JF
机构
[1] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
关键词
D O I
10.1021/ol0353464
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Lactose-appended cyclodextrin derivatives have been synthesized and threaded onto hydrophobic polymers in aqueous solution to form dynamic multivalent lactosides for binding to lectins. The threading process, which proceeds quickly, can be observed by one- and two-dimensional NMR spectroscopies.
引用
收藏
页码:3783 / 3786
页数:4
相关论文
共 58 条
  • [1] AMABILINO DB, 1994, TRENDS POLYM SCI, V2, P146
  • [2] [Anonymous], COMPREHENSIVE SUPRAM
  • [3] Synthesis of glycodendrimers by modification of poly(propylene imine) dendrimers
    Ashton, PR
    Boyd, SE
    Brown, CL
    Nepogodiev, SA
    Meijer, EW
    Peerlings, HWI
    Stoddart, JF
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 1997, 3 (06) : 974 - 984
  • [4] THE SYNTHESIS AND STRUCTURAL MAPPING OF UNSYMMETRICAL CHEMICALLY-MODIFIED ALPHA-CYCLODEXTRINS BY HIGH-FIELD NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY
    ASHTON, PR
    HARTWELL, EY
    PHILP, D
    SPENCER, N
    STODDART, JF
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1995, (07): : 1263 - 1277
  • [5] Polyacrylamide-based glycoconjugates as tools in glycobiology
    Bovin, NV
    [J]. GLYCOCONJUGATE JOURNAL, 1998, 15 (05) : 431 - 446
  • [6] Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions
    Brewer, CF
    Miceli, MC
    Baum, LG
    [J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 2002, 12 (05) : 616 - 623
  • [7] Control of multivalent interactions by binding epitope density
    Cairo, CW
    Gestwicki, JE
    Kanai, M
    Kiessling, LL
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (08) : 1615 - 1619
  • [8] alpha Cyclodextrin/polyethylene glycolpolyrotaxane: A study of the threading process
    Ceccato, M
    LoNostro, P
    Baglioni, P
    [J]. LANGMUIR, 1997, 13 (09) : 2436 - 2439
  • [9] Generation and in situ evaluation of libraries of poly(acrylic acid) presenting sialosides as side chains as polyvalent inhibitors of influenza-mediated hemagglutination
    Choi, SK
    Mammen, M
    Whitesides, GM
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (18) : 4103 - 4111
  • [10] Cyclodextrins: Introduction
    D'Souza, VT
    Lipkowitz, KB
    [J]. CHEMICAL REVIEWS, 1998, 98 (05) : 1741 - 1742