Synthesis of furanone-based natural product analogues with quorum sensing antagonist activity

被引：89

作者：

Hjelmgaard, T

Persson, T

Rasmussen, TB

Givskov, M

Nielsen, J

机构：

[1] Royal Vet & Agr Univ, Dept Chem, DK-1871 Frederiksberg C, Denmark

[2] Tech Univ Denmark, Dept Chem Organ Chem, DK-2800 Lyngby, Denmark

[3] Tech Univ Denmark, Dept Mol Microbiol, BioCtr DTU, DK-2800 Lyngby, Denmark

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 15期

关键词：

D O I：

10.1016/S0968-0896(03)00295-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 5- and 3-(1'-hydroxyalkyl)-substituted 5H-furan-2-ones 4a-d and 8a-d as well as 5-alkylidene-5H-furan-2-ones 5a-d is described. A study of the structure-activity relationship of these furanone-based natural product analogues towards two different quorum sensing systems is reported. Although the synthesized compounds are not as potent quorum sensing inhibitors as some natural counterparts and a synthetic analogue hereof, interesting structure-activity relationships are seen. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3261 / 3271

页数：11

共 41 条

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