Increased xanthine oxidase activity after traumatic brain injury in rats

被引：51

作者：

Solaroglu, I

Okutan, O

Kaptanoglu, E

Beskonakli, E

Kilinc, K

机构：

[1] Hacettepe Univ, Sch Med, Ankara Numune Res & Educ Hosp, Dept Neurol Surg, Ankara, Turkey

[2] Hacettepe Univ, Sch Med, Dept Biochem, Ankara, Turkey

来源：

JOURNAL OF CLINICAL NEUROSCIENCE | 2005年 / 12卷 / 03期

关键词：

brain injury; oxygen free radical; lipid peroxidation; xanthine oxidase;

D O I：

10.1016/j.jocn.2004.12.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Oxidative stress may contribute to many of the pathophysiologic changes that occur after traumatic brain injury (TBI). There are a number of potential sources and mechanisms for oxygen free radical (OFR) production and lipid peroxiclation after TBI. In this study, we investigate the time-dependent changes in xanthine oxidase (XO) activity and lipid peroxiclation using a focal TBI animal model. We demonstrate that there is an immediate increase in lipid peroxiclation by-products and in XO enzyme activity after TBI. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：273 / 275

页数：3

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