The effect of cetirizine on symptoms and signs of nasal polyposis

被引：33

作者：

Haye, R ^{[1
]}

Aanesen, JP

Burtin, B

Donnelly, F

Duby, C

机构：

[1] Rikshosp, Dept Otolaryngol, N-0027 Oslo, Norway

[2] UCB Pharma, Braine Lalleud, Belgium

来源：

JOURNAL OF LARYNGOLOGY AND OTOLOGY | 1998年 / 112卷 / 11期

关键词：

nasal polyps; histamine H-1 receptor blockaders;

D O I：

10.1017/S0022215100142422

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Forty-five patients with residual or recurrent nasal polyposis after ethmoidectomy were treated with either cetirizine at twice the daily recommended (20 mg) dose or placebo for three months. The number and size of polyps remained unchanged during the study period. Cetirizine was found to reduce nasal sneezing and rhinorrhoea effectively. The drug also had a beneficial effect on nasal obstruction in the latter part of the study. The side effects of 20 mg (double the recommended daily adult dose) of cetirizine were few and comparable to placebo.

引用

页码：1042 / 1046

页数：5

共 15 条

[1] INFLUENCE OF H-1-RECEPTOR ANTAGONISTS ON ADHESION MOLECULES AND CELLULAR TRAFFIC [J].