Effects of BCG revaccination on asthma

被引：48

作者：

Choi, IS

Koh, YI

机构：

[1] Chonnam Natl Univ, Sch Med, Dept Internal Med, Gwangju, South Korea

[2] Res Inst Med Sci, Gwangju, South Korea

来源：

ALLERGY | 2003年 / 58卷 / 11期

关键词：

asthma; BCG vaccine; cytokines; lung function;

D O I：

10.1034/j.1398-9995.2003.00246.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

In a study conducted 1 year ago, we found that Th1 immune enhancement following Bacille Calmette-Guerin (BCG) vaccination effectively suppressed human asthma. To investigate whether revaccination would further improve lung function, BCG vaccine was given again. Current lung function tended to improve in the Repeated BCG group (n=9), but not in the Single BCG group (previously the placebo group) (n=11), compared with that 1 year ago. The BCG vaccination improved lung function in both groups, and the Repeated BCG group showed a significant increase in the peripheral blood interferon gamma/interleukin 4 ratio. These findings suggest that repeated BCG vaccinations might be effective in asthma therapy.

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收藏

页码：1114 / 1116

页数：3

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共 8 条

[1] Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease [J].

Arkwright, PD ;

David, TJ .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (03) :531-534

[2] Monocyte derived macrophage cytokine responses induced by M-bovis BCG [J].

Atkinson, S ;

Valadas, E ;

Smith, SM ;

Lukey, PT ;

Dockrell, HM .

TUBERCLE AND LUNG DISEASE, 2000, 80 (4-5) :197-207

[3] The impact of in vivo Calmette-Guerin Bacillus administration on in vitro IgE secretion in atopic children [J].

Barlan, IB ;

Tükenmez, F ;

Bahçeciler, NN ;

Basaran, MM .

JOURNAL OF ASTHMA, 2002, 39 (03) :239-246

[4] Therapeutic effects of BCG vaccination in adult asthmatic patients: a randomized, controlled trial [J].

Choi, IS ;

Koh, YI .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2002, 88 (06) :584-591

[5] Airway hyperresponsiveness, late allergic response, and eosinophilia are reversed with mycobacterial antigens in ovalbumin-presensitized mice [J].

Hopfenspirger, MT ;

Agrawal, DK .

JOURNAL OF IMMUNOLOGY, 2002, 168 (05) :2516-2522

[6] Immunomodulatory effects of CpG oligodeoxynucleotides on established Th2 responses [J].

Kitagaki, K ;

Jain, VV ;

Businga, TR ;

Hussain, I ;

Kline, JN .

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2002, 9 (06) :1260-1269

[7] The effect of delipidated deglycolipidated (DDMV) and heat-killed Mycobacterium vaccae in asthma [J].

Shirtcliffe, PM ;

Easthope, SE ;

Cheng, S ;

Weatherall, M ;

Tan, PLJ ;

Le Gros, G ;

Beasley, R .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (06) :1410-1414

[8] Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells [J].

Zuany-Amorim, C ;

Sawicka, E ;

Manlius, C ;

Le Moine, AL ;

Brunet, LR ;

Kemeny, DM ;

Bowen, G ;

Rook, G ;

Walker, C .

NATURE MEDICINE, 2002, 8 (06) :625-629