Secondary autoimmune diseases occurring after HSCT for an autoimmune disease: a retrospective study of the EBMT Autoimmune Disease Working Party

被引：124

作者：

Daikeler, Thomas ^{[1
]}

Labopin, Myriam ^{[2
]}

Di Gioia, Massimo ^{[3
]}

Abinun, Mario ^{[4
]}

Alexander, Tobias ^{[5
]}

Miniati, Irene ^{[6
]}

Gualandi, Francesca ^{[7
]}

Fassas, Athanasios ^{[8
]}

Martin, Thierry ^{[9
]}

Schwarze, Carl Philipp ^{[10
]}

Wulffraat, Nico ^{[11
]}

Buch, Maya ^{[12
]}

Sampol, Antonia ^{[13
]}

Carreras, Enric ^{[14
]}

Dubois, Benedicte ^{[15
]}

Gruhn, Bernd ^{[16
]}

Guengoer, Tayfun ^{[17
]}

Pohlreich, David ^{[18
]}

Schuerwegh, Annemie ^{[19
]}

Snarski, Emilian ^{[20
]}

Snowden, John ^{[21
,22
]}

Veys, Paul ^{[23
]}

Fasth, Anders ^{[24
]}

Lenhoff, Stig ^{[25
]}

Messina, Chiara ^{[26
]}

Voswinkel, Jan ^{[27
,28
]}

Badoglio, Manuela ^{[29
]}

Henes, Joerg ^{[30
]}

Launay, David ^{[31
]}

Tyndall, Alan ^{[1
]}

Gluckman, Eliane ^{[32
]}

Farge, Dominique ^{[33
]}

机构：

[1] Univ Basel Hosp, Dept Rheumatol, CH-4031 Basel, Switzerland

[2] Hop St Antoine, AP HP, European Blood & Marrow Transplantat Off, Serv Hematol & Therapie Cellulaire, F-75571 Paris, France

[3] Careggi Univ Hosp, Dept Haematol, Florence, Italy

[4] Newcastle Gen Hosp, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[5] Charite, Dept Rheumatol & Clin Immunol, D-13353 Berlin, Germany

[6] Univ Florence, Div Rheumatol, Dept Biomed, Florence, Italy

[7] Osped San Martino Genova, Dept Haematol 2, Genoa, Italy

[8] George Papanicolau Hosp, Thessaloniki, Greece

[9] Univ Strasbourg, Serv Immunol Clin, Strasbourg, France

[10] Univ Childrens Hosp Tubingen, Tubingen, Germany

[11] Univ Med Ctr Utrecht, Utrecht, Netherlands

[12] Univ Leeds, Chapel Allerton Hosp, Sect Musculoskeletal Dis, Leeds, W Yorkshire, England

[13] Hosp Univ Son Espases, Palma de Mallorca, Spain

[14] Hosp Clin Barcelona, Inst Hematol & Oncol, Dept Hematol, Barcelona, Spain

[15] Univ Hosp Leuven, Dept Neurol, Louvain, Belgium

[16] Univ Jena, Dept Pediat, Jena, Germany

[17] Univ Childrens Hosp, Div Immunol Hematol BMT, Zurich, Switzerland

[18] Charles Univ Hosp, Prague, Czech Republic

[19] Leiden Univ, Med Ctr, Dept Rheumatol, Leiden, Netherlands

[20] Med Univ Warsaw, Dept Hematol & Oncol, Cent Clin Hosp, Warsaw, Poland

[21] Sheffield Teaching Hosp Natl Hlth Serv NHS Fdn Tr, Dept Haematol, Sheffield, S Yorkshire, England

[22] Univ Sheffield, Dept Oncol, Sheffield, S Yorkshire, England

[23] Great Ormond St Hosp Sick Children, London, England

[24] Univ Gothenburg, Dept Pediat, Gothenburg, Sweden

[25] Univ Hosp, Dept Hematol, Lund, Sweden

[26] Clin Oncoematol Pediat, Dipartimento Pediat, Padua, Italy

[27] Hop St Antoine, AP HP, Dept Hematol, F-75571 Paris, France

[28] Univ Paris 06, Paris, France

[29] CEREST TC European Blood & Marrow Transplantat, European Blood & Marrow Transplantat Study Off, Fac Med St Antoine, Unite Mixte Rech S938, Paris, France

[30] Univ Tubingen Hosp, Dept Hematol & Rheumatol, Tubingen, Germany

[31] Hop Claude Huriez, Dept Internal Med, Lille, France

[32] Hop St Louis, AP HP, Eurocord Off, Clin Res Unit, Paris, France

[33] St Louis Hosp, INSERM, Internal Med & Vasc Pathol Unit, U976, Paris, France

来源：

BLOOD | 2011年 / 118卷 / 06期

关键词：

STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; HEMOLYTIC-ANEMIA; BLOOD;

D O I：

10.1182/blood-2011-02-336156

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To specify the incidence and risk factors for secondary autoimmune diseases (ADs) after HSCT for a primary AD, we retrospectively analyzed AD patients treated by HSCT reported to EBMT from 1995 to 2009 with at least 1 secondary AD (cases) and those without (controls). After autologous HSCT, 29 of 347 patients developed at least 1 secondary AD within 21.9 (0.6-49) months and after allogeneic HSCT, 3 of 16 patients. The observed secondary ADs included: autoimmune hemolytic anemia (n = 3), acquired hemo- philia (n = 3), autoimmune thrombocytopenia (n = 3), antiphospholipid syndrome (n = 2), thyroiditis (n = 12), blocking thyroid-stimulating hormone receptor antibody (n = 1), Graves disease (n = 2), myasthenia gravis (n = 1), rheumatoid arthritis (n = 2), sarcoidosis (n = 2), vasculitis (n = 1), psoriasis (n = 1), and psoriatic arthritis (n = 1). After autologous HSCT for primary AD, the cumulative incidence of secondary AD was 9.8% +/- 2% at 5 years. Lupus erythematosus as primary AD, and antithymocyte globulin use plus CD34(+) graft selection were important risk factors for secondary AD by multivariate analysis. With a median follow-up of 6.2 (0.54-11) years after autologous HSCT, 26 of 29 patients with secondary AD were alive, 2 died during their secondary AD (antiphospholipid syndrome, hemophilia), and 1 death was HSCT-related. This European multicenter study underlines the need for careful management and follow-up for secondary AD after HSCT. (Blood. 2011;118(6):1693-1698)

引用

页码：1693 / 1698

页数：6

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